造血祖细胞激酶1蛋白激酶在肿瘤中的研究进展

Research progress of HPK1 protein kinase in tumor

造血祖细胞激酶1(hematopoietic progenitor kinase 1,HPK1),也称MAP4K1,是一种丝氨酸/苏氨酸蛋白激酶,是哺乳动物Ste20相关蛋白激酶MAP4K家族的一员。近来研究发现,HPK1与多种肿瘤的发生、进展有关联,在一些恶性肿瘤中可能起重要作用。该文对HPK1信号通路、与肿瘤的关系以及药物研发进展做一综述,为HPK1蛋白激酶的研究提供参考。

Hematopoietic progenitor kinase 1(HPK1),also known as MAP4K1,is a serine/threonine protein kinase and a member of the MAP4K family of mammalian Ste20-related protein kinases.Recent studies have found that HPK1 is associated with the occurrence and progression of a variety of tumors,and may play an important role in some malignant tumors.This paper reviews the HPK1 signaling pathway,its relationship with tumor and drug development progress,so as to provide reference for the research of HPK1 protein kinase.