野生型p53诱导的磷酸酶1在常见慢性疾病中的作用及相关分子生物学机制

Role of wild-type p53 induced phosphatase 1 in common chronic diseases and its related molecular biological mechanism

野生型p53诱导的磷酸酶1(Wip1)由PPM1D基因编码,是蛋白磷酸酶2C家族的成员。早期研究发现,Wip1在多种人类肿瘤中过度表达,参与肿瘤发生、进展、侵袭及远处转移。在分子层面,Wip1与多种信号通路网络中分子蛋白磷酸化的时空调控相关联。近年来大量研究发现,Wip1还在包括神经发生、造血干细胞稳态和心血管疾病等多种生物学功能中发挥作用。本文将对Wip1在肿瘤、造血干细胞稳态、成体神经发生及心血管疾病等常见慢性疾病分子生物学中的研究进展进行综述。

As a member of the protein phosphatase type 2C(PP2C)family,wild-type p53 induced phosphatase 1(Wip1)is encoded by PPM1D.Previous researches have shown that overexpressed in various types of human tumors,Wip1 serves a major role in tumorigenesis,progression,invasion and distant metastasis.At the molecular level,Wip1 plays an important role in the spatial and temporal regulation of protein phosphorylation in numerous signaling pathways.Many recent studies have found that Wip1 also partici-pates in several biological processes,such as neurogenesis,haematopoietic stem cell homeostasis and cardiovascular disease.In this article,we review the research progress of roles of Wip1 in the molecular mechanism of neoplasm,haematopoietic stem cell homeostasis,adult neurogenesis,and cardiovascular disease.