索凡替尼致急性肾损伤的病例分析

Case Analysis of Surufatinib-induced Acute Kidney Injury

1例43岁女性患者因左上颌恶性肿瘤术后复发,口服索凡替尼300 mg·d^(-1),4周为一个周期。治疗第4周期出现蛋白尿、高血压、高血脂、水肿和低白蛋白血症,血肌酐升高。立即停用索凡替尼,给予降尿蛋白、降压及对症治疗。肾活检示血栓性微血管病变,判定为索凡替尼所致急性肾损伤。经治疗后患者尿蛋白逐渐减少,血压下降,血肌酐恢复正常。

A 43-year-old female patient with postoperative recurrence of left maxillary malignant tumor was treated with surufatinib 300 mg·d^(-1)orally for 4 weeks as one cycle.In the fourth treatment cycle,proteinuria,hypertension,hyperlipidemia,edema and hypoalbuminemia occurred,and serum creatinine increased.Surufatinib was discontinued immediately after admission,and symptomatic treatment was given to reduce urinary protein and blood pressure.Renal biopsy showed thrombotic microangiopathy,which was judged to be acute kidney injury caused by surufatinib.One week later,the patient was discharged as her urinary protein gradually decreased,blood pressure decreased and serum creatinine returned to normal.