雷替曲赛联合奥沙利铂治疗老年晚期结直肠癌的临床效果

Clinical effect of raltitrexed combined with oxaliplatin in the treatment of elderly patients with advanced colorectal cancer

目的 探讨雷替曲赛联合奥沙利铂治疗老年晚期结直肠癌的临床效果。方法 选择2019年6月至2021年5月我院接收的80例老年晚期结直肠癌患者为研究对象,依据入院编号的奇偶性将其分为参照组与试验组,各40例。参照组实施氟尿嘧啶联合奥沙利铂治疗,试验组实施雷替曲赛联合奥沙利铂治疗。比较两组的治疗效果。结果 试验组的治疗总有效率高于参照组(P<0.05)。试验组的转氨酶升高总发生率高于参照组,其他并发症总发生率低于参照组,差异具有统计学意义(P<0.05)。治疗后,两组的生活质量、体力状况评分及身体质量指数均升高,临床症状评分均降低,且试验组优于参照组(P<0.05)。结论 替曲赛联合奥沙利铂治疗老年晚期结直肠癌的临床效果显著,可降低各项并发症总发生率,改善患者的生活质量。

Objective To investigate the clinical effect of raltitrexed combined with oxaliplatin in the treatment of elderly patients with advanced colorectal cancer.Methods A total of 80 elderly patients with advanced colorectal cancer admitted in our hospital from June 2019 to May 2021 were selected as the objects.According to the parity of admission number,the patients were divided into reference group and experimental group,with 40 cases in each group.The reference group was treated with fluorouracil combined with oxaliplatin,and the experimental group was treated with raltitrexed combined with oxaliplatin.The therapeutic effects were compared between the two groups.Results The total effective rate of treatment in the experimental group was higher than that in the reference group(P<0.05).The total incidence of transaminase elevation in the experimental group was higher than that in the reference group,the total incidence of other complications were lower than those in the reference group,and the differences were statistically significant(P<0.05).After treatment,the scores of quality of life and physical condition and body mass index of the two groups increased,the score of clinical symptoms decreased,and those in the experimental group were better than the reference group(P <0.05).Conclusion Raltitrexed combined with oxaliplatin in the treatment of elderly patients with advanced colorectal cancer has remarkable clinical effect,which can reduce the total incidence of complications and improve the quality of life.