门冬氨酸钾镁联合胺碘酮治疗急性心肌梗死室性心律失常的临床效果及对患者心功能的影响

Clinical effect of potassium magnesium aspartate combined with amiodarone on ventricular arrhythmia in cute myocardial infarction and its influence on cardiac function of patients

目的 探讨门冬氨酸钾镁联合胺碘酮治疗急性心肌梗死室性心律失常的临床效果及对患者心功能的影响。方法 选取我院2019年1月至2020年12月收治的100例急性心肌梗死室性心律失常患者作为研究对象,按照治疗方案不同将其分为对照组(n=50,胺碘酮)和观察组(n=50,门冬氨酸钾镁+胺碘酮)。比较两组患者的治疗效果、血钾、血镁水平、心功能指标、左心功能指标、不良反应发生情况及心率变异性(HRV)指标。结果 观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的血钾、血镁水平高于对照组(P<0.05)。治疗后,两组的左心室舒张末期内径(LVEDD)均缩短,左室射血分数(LVEF)、心输出量(CO)均增大,且观察组优于对照组(P<0.05)。治疗后,观察组的平均左室舒张晚期峰值应变率(mSRa)、平均左室舒张早期峰值应变率(mSRe)低于对照组,平均左室收缩期峰值应变率(mSRs)高于对照组,差异具有统计学意义(P<0.05)。观察组的不良反应总发生率略低于对照组,但差异无统计学意义(P>0.05)。治疗后,两组的总体标准差(SDNN)、每5 min平均正常窦性心搏间期的标准差(SDANN)、相邻正常窦性心搏间期差值的均方根(RMSSD)、相邻正常窦性心搏间期差值超过50 ms的个数占总窦性心搏数的百分比(PNN50)均升高,且观察组高于对照组(P<0.05)。结论 门冬氨酸钾镁联合胺碘酮治疗急性心肌梗死室性心律失常的临床效果显著,可改善患者的血钾、血镁水平及心功能,且用药安全性较高。

Objective To explore the clinical effect of potassium magnesium aspartate combined with amiodarone on ventricular arrhythmia in acute myocardial infarction and its influence on cardiac function of patients.Methods A total of100 patients with ventricular arrhythmia in acute myocardial infarction treated in our hospital from January 2019 to December 2020 were selected as the research objects,and the patients were divided into control group(n=50,amiodarone)and observation group(n=50,potassium magnesium aspartate + amiodarone) according to different treatment schemes.The therapeutic effect,blood potassium and magnesium levels,cardiac function indexes,left ventricular function indexes,occurrence of adverse reactions and heart rate variability(HRV) indexes were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group(P0.05).After treatment,the stabdard devuatuion of NN intervals(SDNN),standard diviation of average NN intervals(SDANN),root mean square of successive difference(RMSSD) and the proportion of adjacent NN intervals differing by > 50 ms(PNN50) in the two groups increased,and those in the observation group were higher than the control group(P<0.05).Conclusion Potassium magnesium aspartate combined with amiodarone on ventricular arrhythmia with acute myocardial infarction has a significant clinical effects,it can improve the levels of blood potassium and magnesium,and cardiac function of patients,and has a high safety.