半夏秫米汤加减治疗伴失眠的抑郁障碍的临床研究

Clinical Study on Modified Banxia Shumi Decoction in the Treatment of Depressive Disorder with Insomnia

目的:研究半夏秫米汤加减治疗伴失眠的抑郁障碍的临床效果。方法:本研究选取2019年6月至2021年12月在江西省精神病院伴失眠的抑郁障碍患者70例,按随机数字表法分组,对照组(35例)采用盐酸米安色林片治疗。观察组(35例)采用半夏秫米汤加减治疗。观察两组治疗6周后临床病情控制优良率,治疗2周、4周、6周后汉密尔顿抑郁量表(HAMD)评分、匹兹堡睡眠质量指数量表(PSQI)评分、药物副作用量表(TESS)评分。结果:治疗6周后,两组临床病情控制优良率比较,差异无统计学意义(P>0.05);两组治疗前、治疗2周、4周、6周后,组间HAMD量表评分、PSQI量表评分比较,差异无统计学意义(P>0.05);治疗6周后,观察组TESS量表评分,低于对照组(P<0.05)。结论:半夏秫米汤加减治疗伴失眠的抑郁障碍患者,能够达到与盐酸米安色林片相同的治疗效果,但用药安全性更高。

Objective:To study the clinical effect of modified banxia shumi decoction on depressive disorder with insomnia.Methods:70 patients who depressive disorder cases with insomnia in Jiangxi Psychiatric Hospital from June 2019 to December 2021 were selected and grouped according to random number table method.The control group (35 cases) was treated with mianselin hydrochloride tablets.The observation group (35 cases) was treated with modified banxia shumi decoction.Observe the excellent and good rate of clinical condition control in two group after 6 weeks of treatment,hamilton depression scale (HAMD),Pittsburgh sleep quality index (PSQI) and drug side effects scale (TESS) scores after 2,4 and 6 weeks of treatment were observed.Results:After 6 weeks of treatment,there was no significant difference in the excellent rate of clinical condition control between the two groups (P>0.05).There was no significant difference in HAMD scale score and PSQI scale score between the two groups before treatment,2 weeks,4 weeks and 6 weeks after treatment (P>0.05).After 6 weeks of treatment,theTESS score of the observation group was lower than that of the control group (P<0.05).Conclusion:The modified banxia shumi decoction can achieve the same therapeutic effect as mianselin hydrochloride tablets in the treatment of depression patients with insomnia,but the drug safety is higher.