非小细胞肺癌病人常见免疫治疗不良反应的影响因素分析

Influencing factors of common adverse reactions of immunotherapy in patients with non-small cell lung cancer

目的:分析非小细胞肺癌病人免疫治疗不良反应的发生情况及影响因素。方法:采用一般情况调查表、中医体质分类与判定量表及CTCAE不良反应调查表,对110例非小细胞肺癌(NSCLC)首次予帕博利珠单抗免疫治疗病人进行调查。结果:单因素分析,吸烟史、饮酒史、手术治疗史、化疗史、中医体质是疲乏的影响因素;性别、吸烟史、吸烟指数、过敏史、TNM分期、化疗史、中医体质是皮疹的影响因素;职业、过敏史、TNM分期、化疗史、中医体质是瘙痒的影响因素;性别、婚姻状况、吸烟史、饮酒史、过敏史、手术治疗史、化疗史、中医体质是腹泻的影响因素。logistic回归分析,饮酒史是其发生疲乏的主要影响因素;吸烟史、吸烟指数是其发生皮疹的主要影响因素;变量均不是其发生瘙痒的主要影响因素,手术治疗史是其发生腹泻的主要影响因素。结论:医务人员要采取预见性干预措施,以降低因免疫治疗发生的不良反应。

Objective:To analyze the occurrence of immunotherapy adverse reactions in patients with non-small cell lung cancer(NSCLC)and influencing factors.Methods:The general investigation table,the medical treatment and judgment meter and CTCAE adverse reactions survey were investigated in 110 NSCLC patients for the first time to use Pembrolizumab.Results:Single factor analysis showed that smoking history,drinking history,surgery history,chemotherapy history,Chinese medicine physique were the influencing factors of fatigue;gender,smoking history,smoking index,allergy history,TNM staging,chemotherapy history,Chinese medicine physics were the influencing factors of rash.Career,allergic history,TNM grading,chemotherapy history,Chinese medicine physique were the influencing factor of itching;gender,marital status,smoking history,drinking history,allergy history,surgery history,chemotherapy history,Chinese medicine physiothema were the influencing factors of diarrhoea.Logistic regression analysis showed that,the history of drinking was the main influencing factor in which the smoking is a history of smoking.The main influencing factors of the rash occurred;variables are not the main influencing facto of itch,and the history of surgery is a diarrhea.The main influencing factors.Conclusions:Medical staff should take predictive interventions to reduce immune-related adverse reactions.