心肌梗死患者采用血清Gal-3、GDF-15、CK-MB联合检测的效果评价分析

Evaluation and Analysis of Combined Detection of Serum Gal-3,GDF-15 and CK-MB in Patients with Myocardial Infarction

目的 探究心肌梗死患者采用血清半乳糖凝集素-3(galectin-3,Gal-3)、生长分化因子-15(growth differentiation factor-15,GDF-15)、肌酸激酶同工酶(creatine kinase isoenzymes,CK-MB)联合检测的效果。方法 将济南市第一人民医院2019年5月—2020年5月收治的50例心肌梗死患者作为观察组,另选取50名同期健康体检者为对照组,对血清Gal-3、GDF-15、CK-MB联合检测,探讨其对心肌梗死的诊断效果。结果 观察组Gal-3、GDF-15、CK-MB浓度显著高于对照组,差异有统计学意义(P<0.05);联合诊断的ROC曲线下面积为0.907(95%CI:0.772~0.976),联合诊断与Gal-3、GDF-15、CK-MB比较,差异有统计学意义(Z=5.765、2.595、2.555,P<0.05)。结论 心肌梗死患者血清Gal-3、GDF-15、CK-MB浓度呈显著上升状态,可以结合三者水平,作为筛选心肌梗死患者的指标之一。

Objective To explore the effect of combined detection of serum galectin-3(Gal-3),growth differentiation factor-15(GDF-15) and creatine kinase isoenzymes(CK-MB) in patients with myocardial infarction.Methods 50 patients with myocardial infarction treated in Jinan First People’s Hospital from May 2019 to May 2020 were selected as the observation group,and 50 healthy people who underwent physical examination during the same period were selected as the control group.Combined detection of serum Gal-3,GDF-15 and CK-MB to explore their diagnostic effect on myocardial infarction.Results The concentrations of Gal-3,GDF-15 and CK-MB in the observation group were significantly higher than those in the control group,the difference was statistically significant(P<0.05);the area under the ROC curve of combined diagnosis was 0.907(95%CI:0.772-0.976),compared with Gal-3,GDF-15,and CK-MB in combined diagnosis,the difference was statistically significant(Z=5.765,2.595,2.555,P<0.05).Conclusion Serum concentrations of Gal-3,GDF-15,and CK-MB in patients with myocardial infarction were significantly increased.The three levels can be combined as one of the indicators for screening patients with myocardial infarction.