探讨老年糖尿病患者临床检验尿白蛋白、免疫球蛋白G及β_(2)微球蛋白临床分析

Clinical Analysis of Urine Albumin,Immunoglobulin G and β_(2) Microglobulin in Elderly Diabetic Patients

目的 阐述对老年糖尿病患者应用尿白蛋白、免疫球蛋白G及β_(2)微球蛋白指标的临床检验效果,让患者获得及时治疗。方法 选取2017年1月—2020年6月东海县人民医院收治的老年糖尿病患者80例为研究组,另选同时间段的健康体检者80名为常规组,观察两组的尿白蛋白、免疫球蛋白G及β_(2)微球蛋白指标;研究组患者在接受联合检测手段及单一检测手段的阳性诊断率,评价不同检查手段对检查患者的作用效果(诊断金标准:根据ADA推荐检查所有患者HbA1c水平超过6.5%,可考虑诊断为糖尿病;所有检查阳性率100.0%表示患者病情均精准确诊)。结果 研究组尿白蛋白(18.22±3.26)mg/L、β_(2)微球蛋白(194.78±8.10)mg/L、免疫球蛋白G(10.30±3.50)g/L均高于常规组,差异有统计学意义(t=33.448、64.425、15.864,P<0.05)。研究组中单一检测阳性率(尿白蛋白71.3%、β_(2)微球蛋白67.5%、免疫球蛋白G 70.0%)均低于联合检测法(95.0%),差异有统计学意义(χ^(2)=12.000、12.890、14.700,P<0.05)。研究组患病1.0年中,A1b(34.67±5.41)mg/L、IgG(13.41±4.07)g/L、β_(2)mG(2.91±1.29)mg/L,患病3.0年中A1b(601.24±83.40)mg/L、IgG(65.56±8.23)g/L、β_(2)mG(8.41±2.01)mg/L,差异有统计学意义(t=64.811、112.126、68.324,P<0.05)。结论 老年糖尿病患者在疾病诊断中依靠免疫球蛋白G、尿白蛋白及β_(2)微球蛋白指标结果判断准确,便于及时开展治疗控制血糖水平,应用价值良好。

Objective To describe the clinical test results of urinary albumin,immunoglobulin G and β_(2)microglobulin in elderly patients with diabetes,so that patients can get timely treatment.Methods A total of 80 elderly diabetic patients admitted to Donghai County People’s Hospital from January 2017 to June 2020 were selected as the study group,and 80 healthy subjects during the same time period were selected as the routine group.The urine albumin,immunoglobulin G and β_(2)microglobulin indexes of the two groups were observed.The positive diagnosis rate of the patients in the study group receiving the combined detection method and the single detection method,and the effect of different examination methods on the patients was evaluated(the gold standard for diagnosis:according to the ADA recommendation,the HbA1c level of all patients was more than 6.5%,and the diagnosis of diabetes can be considered,the positive rate of all tests was 100%,indicating that the patient’s condition was accurately diagnosed).Results The urine albumin(18.22±3.26) mg/L,β_(2)microglobulin(194.78±8.10) mg/L,and immunoglobulin G(10.30±3.50) g/L of the study group were all higher than those of the routine group,the difference was statistically significant(t=33.448,64.425,15.864,P<0.05).In the study group,the positive rate of single test(urinary albumin 71.3%,β_(2)microglobulin 67.5%,and immunoglobulin G 70.0%) were lower than those of the combined detection method(95.0%),the difference was statistically significant(χ^(2)=12.000,12.890,14.700,P<0.05).During 1.0 years of illness in the study group,A1b(34.67±5.41) mg/L,IgG(13.41±4.07) g/L,β_(2)mG(2.91±1.29) mg/L,during 3.0 years of illness,A1b(601.24±83.40) mg/L,IgG(65.56±8.23) g/L,β_(2)mG(8.41±2.01) mg/L,the difference was statistically significant(t=64.811,112.126,68.324,P<0.05).Conclusion Elderly diabetic patients rely on the results of immunoglobulin G,urine albumin and β_(2)microglobulin to make accurate judgments in disease diagnosis,which is convenient for timely treatment to control blood glucose levels,and has good application value.