高胆红素血症新生儿血清vWF、TBA、Cys C水平与其凝血功能的相关性

Correlation of serum vWF,TBA and Cys C levels with their coagulation function in hyperbilirubinemia neonates

目的探讨高胆红素血症新生儿血清血管性假血友病因子(vWF)、总胆汁酸(TBA)、胱抑素C(Cys C)水平与其凝血功能的相关性。方法选取2020年5-12月于该院就诊的高胆红素血症新生儿100例为观察组,另选取在该院进行顺产的100例健康足月儿为对照组。比较两组及不同严重程度患儿的vWF、TBA、Cys C水平之间的差异,分析vWF、TBA、Cys C水平与其凝血功能的相关性。结果观察组vWF、TBA、Cys C水平高于对照组(P<0.05);不同严重程度患儿vWF、TBA、Cys C水平比较,差异有统计学意义(P<0.05)。3组患儿的vWF、TBA、Cys C水平从高到低依次为重度组、中度组、轻度组。观察组患儿的活化部分凝血活酶时间(APTT)长于对照组,D-二聚体(DD)水平高于对照组,差异有统计学意义(P<0.05),但两组的PT、TT比较,差异无统计学意义(P>0.05)。vWF、TBA、Cys C水平与APTT、DD均呈正相关(P<0.05)。结论高胆红素血症新生儿血清vWF、TBA、Cys C水平与其凝血功能有关。

Objective To investigate the correlation of serum von Willebrand factor(vWF),total bile acid(TBA)and cystatin C(Cys C)levels with their coagulation function in neonates with hyperbilirubinemia.Methods A total of 100 neonates with hyperbilirubinemia who were treated in this hospital from May to December 2020 were selected as the observation group,and 100 healthy full-term infants who underwent vaginal delivery in the hospital were selected as the control group.The differences of vWF,TBA,Cys C levels between the two groups and children with different severity were compared,and the correlation between vWF,TBA,Cys C levels and their coagulation function was analyzed.Results The levels of vWF,TBA and Cys C in the observation group were higher than those in the control group(P<0.05);there were significant differences in the levels of vWF,TBA and Cys C in children with different severity(P<0.05).The levels of vWF,TBA and Cys C in the three groups were from high to low:severe group,moderate group and mild group.The activated partial thromboplastin time(APTT)of the observation group was longer than that of the control group,and the D-dimer(DD)level was higher than that of the control group,and the difference was statistically significan(P<0.05).However,there was no significant difference in PT and TT between the two groups(P>0.05).The levels of vWF,TBA and Cys C were positively correlated with APTT and DD(P<0.05).Conclusion The serum levels of vWF,TBA and Cys C in neonates with hyperbilirubinemia are related to their coagulation function.