针灸对早期重症急性胰腺炎肠屏障功能障碍及胃肠激素的影响

Effects of acupuncture and moxibustion on intestinal barrier dysfunction and gastrointestinal hormones in early severe acute pancreatitis

目的探讨针灸对早期重症急性胰腺炎(SAP)患者肠屏障功能障碍及胃肠激素的影响。方法选取2018年7月至2020年3月于该院就诊的78例SAP患者为研究对象,将其随机分为治疗组和对照组,每组39例。测定治疗前、治疗后4 d及7 d患者血浆内毒素(ET)、二胺氧化酶(DAO)及胃动素(MOT)水平。结果与治疗前比较,两组治疗后4、7 d ET水平逐渐降低(P<0.05),治疗组较对照组降低更明显(P<0.05);治疗组治疗后4、7 d DAO水平降低(P<0.05),对照组治疗后4 d DAO水平升高,治疗后7 d DAO水平降低(P<0.05);治疗组治疗后4、7 d DAO水平低于对照组(P<0.05);两组治疗后4、7 d MOT水平升高(P<0.05),治疗组较对照组升高更明显(P<0.05)。结论针灸能明显改善早期SAP患者的肠屏障功能。

Objective To investigate the effect of acupuncture and moxibustion on intestinal barrier dysfunction and gastrointestinal hormones in patients with early severe acute pancreatitis(SAP).Methods A total of 78 SAP patients in the hospital from July 2018 to March 2020 were selected as the research objects,and they were randomly divided into a treatment group and a control group,with 39 cases in each group.Plasma endotoxin(ET),diamine oxidase(DAO)and motilin(MOT)levels were measured before treatment,4 d and 7 d after treatment.Results Compared with before treatment,the levels of ET in the two groups gradually decreased at 4 d and 7 d after treatment(P<0.05),and the decrease in the treatment group was more obvious than that in the control group(P<0.05).The DAO level in the treatment group decreased at 4 d and 7 d after treatment(P<0.05),while the DAO level in the control group increased at 4 d after treatment and decreased at 7 d after treatment(P<0.05).The DAO levels in the treatment group were lower than those in the control group at 4 d and 7 d after treatment(P<0.05).The levels of MOT in the two groups increased at 4 d and 7 d after treatment(P<0.05),and the treatment group increased more significantly than the control group(P<0.05).Conclusion Acupuncture can significantly improve the intestinal barrier function of early SAP patients.