联合检测血清GP73和AFP对原发性肝癌诊断价值的探讨

Value of Combined Detection of Serum GP73 and AFP in the Diagnosis of Primary Liver Cancer

目的分析在原发性肝癌(primary hepatic carcinoma,PHC)诊断中,采取血清GP73和AFP联合检测的临床价值。方法选取扬州大学附属医院2021年1—12月收治的20例PHC患者为研究对象,将其纳入PHC组;同时选取同时期收治的20例肝硬化(liver cirrhosis,LC)患者纳入LC组;20例慢性乙型肝炎(chronic hepatitis B,CHB)患者纳入CHB组;20名健康体检者纳入参照组。针对入选人员均采取血清学GP73和AFP检验,对比单一血清学指标检验与联合检验的临床价值。结果4组受检者血清GP73、AFP水平方面,PHC组>LC组>CHB组>参照组,差异有统计学意义(P<0.05)。PHC组不同检测方案阳性检出率明显高于LC组、CHB组与参照组,差异有统计学意义(P<0.05);LC组、CHB组对比差异无统计学意义(P>0.05),CHB组、参照组对比,差异无统计学意义(P>0.05)。80例受检者中阳性20例(PHC患者)、阴性60例(非PHC患者);单一血清GP73检测,阳性14例、阴性66例;单一血清AFP检测阳性14例、阴性66例;联合血清GP73+AFP检测,阳性19例、阴性61例;联合检测诊断的阳性检出率为23.75%(19/80),诊断符合率为96.25%(77/80);单一GP73的阳性检出率为17.50%(14/80),诊断符合率为87.50%(70/80);单一AFP的阳性检出率为17.50%(14/80),诊断符合率为85.00%(68/80)。结论在PHC诊断中,采取血清GP73和AFP联合检测诊断效能显著高于单一血清GP73或AFP,具有较高的临床应用价值。

Objective To analyze the clinical value of combined detection of serum GP73 and AFP in the diagnosis of primary liver cancer(PHC).Methods 20 PHC patients admitted to Affiliated Hospital of Yangzhou University from January to December 2021 were selected as the research objects and included in the PHC group.At the same time,20 patients with liver cirrhosis(LC)admitted during the same period were selected into the LC group,20 patients with chronic hepatitis B(CHB)were included in the CHB group,and 20 healthy subjects were included in the reference group.Serological GP73 and AFP tests were taken for all selected persons to compare the clinical value of single serological index test and combined test.Results In terms of serum GP73 and AFP levels of the four groups of subjects,PHC group>LC group>CHB group>reference group,the difference was statistically significant(P<0.05).The positive detection rate of different detection schemes in the PHC group was significantly higher than that in the LC group,the CHB group and the reference group,and the difference was statistically significant(P<0.05).There was no statistically significant difference between the group and the reference group(P>0.05).Among the 80 subjects tested,20 were positive(PHC patients)and 60 were negative(non-PHC patients);single serum GP73 test was positive in 14 cases and negative in 66 cases;single serum AFP test was positive in 14 cases and negative in 66 cases;combined serum GP73+AFP test,19 cases were positive and 61 cases were negative;the positive detection rate of combined detection and diagnosis was 23.75%(19/80),and the diagnostic coincidence rate was 96.25%(77/80);the positive detection rate of single GP7317.50%(14/80),the diagnostic coincidence rate was 87.50%(70/80);the positive detection rate of single AFP was 17.50%(14/80),and the diagnostic coincidence rate was 85.00%(68/80).Conclusion In the diagnosis of PHC,the combined detection of serum GP73 and AFP has a significantly higher diagnostic efficiency than single serum GP73 or AFP,which has high clinical application value.