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多发性骨髓瘤自体干细胞动员采集的优化及实践 被引量:2

Optimization and practice of mobilization and collection of autologous stem cells in multiple myeloma
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摘要 多发性骨髓瘤(MM)是一种克隆浆细胞异常增殖的恶性疾病,是常见的血液系统恶性肿瘤,多发于老年^([1])。新近发布的大型流行病学调查显示:2016年,全球MM年龄标准化发病率(ASIR)和死亡率(ASDR)分别为2.1/10万人和1.5/10万人;澳大拉西亚(ASIR 5.8/10万人,ASDR 2.8/10万人)、高收入北美地区(ASIR 5.2/10万人,ASDR 3.0/10万人)、西欧(ASIR 4.6/10万人,ASDR 2.6/10万人)是全球MM发病率和死亡率最高的3个地区^([2])。
作者 傅琤琤 顔霜 金松 吴德沛 FU Cheng-cheng;YAN Shuang;JIN Song
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2022年第7期582-587,600,共7页 Chinese Journal of Practical Internal Medicine
基金 国家科技重大专项课题(2017ZX09304021) 国家重点研发计划(2019YFC0840604,2017YFA0104502) 江苏省重点研发计划(BE2019798) 江苏省医学杰出人才项目(JCRCA2016002) 江苏省科教强卫工程-临床医学中心(YXZXA2016002) 国家血液系统疾病临床医学研究中心转化研究开放课题ZKPB01(2020ZKPB01)。
关键词 多发性骨髓瘤 自体造血干细胞移植 干细胞动员 干细胞采集 multiple myeloma autologous stem cell transplantation stem cell mobilization stem cell collection
  • 相关文献

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  • 1Cavo M, Baccarani M. The changing landscape of myeloma thera- py. N Engl J Med, 2006, 354:1076-1078.
  • 2Kumar SK, Rajkumar SV, Dispenzieri A, et al. Improved survival in multiple myeloma and the impact of novel therapies. Blood, 2008,111:2516-2520.
  • 3Anderson KC, Alsina M, Bensinger W, et al. NCCN clinical practice guidelines in oncology: multiple myeloma. J Natl Compr Canc Netw, 2009,7:908-942.
  • 4Nucci M, Anaissie E. Infections in patients with multiple myeloma in the era of high-dose therapy and novel agents. Clin Infect Dis, 2009, 49: 1211-1225.
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  • 7Blad J, SamsonD, Reece D, et al. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high dose therapy and hemopoietic stem cell transplantation. Myeloma Subcommittee of the EMBT. European Group for Blood and Marrow Transplant. Br J Haematol, 1998,102 : 1115-1123.
  • 8Seder RA, Ahmed R. Similarities and differences in CD4 and CD8 effector and memory T cell generation. Nat Immunol, 2003, 4:835-842.
  • 9Reimer P, Kunzmann V, Wilhelm M, et al. Cellular and hurnoral immune reconstitution after autologous peripheral blood stem cell transplantation (PBSCT). Ann Hematol, 2003, 82 : 263 -270.
  • 10Nachbaur D, Kropshofer G, Heitger A, et al. Phenotypic and functional lymphocyte recovery after CD34 +-enriched versus non-T cell-depleted autologous peripheral blood stem cell trans- plantation. J Hematother Stem Cell Res, 2000, 9:727-736.

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