养阴润肠消导方辅助治疗儿童功能性便秘阴虚气滞证的效果及对血清胃肠激素水平的影响

Effects of Yangyin Runchang Xiaodao Fang(养阴润肠消导方)in adjuvant treatment of functional constipation in children with yin⁃deficiency and qi stagnation syndrome and its influence on serum gastrointestinal hormone levels

目的观察养阴润肠消导方辅助治疗儿童功能性便秘阴虚气滞证的效果及对血清胃肠激素水平的影响。方法选取2019年6月至2020年12月浙江省立同德医院儿科收治的功能性便秘阴虚气滞证患儿112例,按照随机数字表法分为对照组和治疗组,各56例。对照组予乳果糖口服液口服,治疗组在对照组治疗方法的基础上予养阴润肠消导方口服。2组均7 d为1个疗程,连续治疗2个疗程后统计疗效。结果治疗前,2组中医证候评分比较,差异均无统计学意义(P>0.05),具有可比性;治疗后,2组中医证候评分均显著降低,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。对照组总有效率为78.57%(44/56),治疗组为91.07%(51/56),2组比较,差异有统计学意义(P<0.05)。治疗前,2组血清胃动素(MTL)、胃泌素(GAS)、生长抑素(SS)水平比较,差异均无统计学意义(P>0.05),具有可比性;治疗后,2组血清SS水平显著下降,GAS、MTL水平显著升高,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组下降或升高更显著(P<0.05)。结论养阴润肠消导方辅助治疗儿童功能性便秘阴虚气滞证,能明显改善临床症状,调节胃肠激素水平,疗效显著,值得临床推广应用。

Objective To observe the effects of Yangyin Runchang Xiaodao Fang(养阴润肠消导方,YRXF)in adjuvant treatment of functional constipation(FC)in children with yin⁃deficiency and qi stagnation syndrome and its influence on serum gastrointestinal hormone levels.Methods From June 2019 to December 2020,112 cases of FC in children with yin⁃deficiency and qi stagnation syndrome admitted into pediatrics department of Tongde Hospi⁃tal of Zhejiang Province were divided into control group and treatment group according to random number table method,with 56 cases in each group.The control group was given oral administration of lactulose oral solution,on this basis,the treatment group was given oral administration of YRXF.Seven days constituted 1 course of treatment for both groups,and we kept statistics about the efficacy after consecutive 2 courses of treatment.Results Before treatment,the difference was not statistically significant in TCM symptom score between the 2 groups(P>0.05),in⁃dicating comparability.After treatment,TCM symptom score of the 2 groups all significantly decreased,and the difference was statistically significant than the same group before treatment(P<0.05),moreover,the treatment group decreased more significantly(P<0.05).The total effective rate was 78.57%(44/56)in the control group and 91.07%(51/56)in the treatment group,and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,there was no statistically significant difference in the serum levels of motilin(MTL),gastrin(GAS)and somatostatin(SS)between the 2 groups(P>0.05),indicating comparability.After treatment,the serum levels of SS decreased significantly and the levels of GAS and MTL increased significantly in the 2 groups,and the difference was statistically significant than those in the same group before treatment(P<0.05),moreover,the decrease or increase in the treatment group was more significant(P<0.05).Conclusion YRXF can significant⁃ly improve clinical symptoms and regulate the level of gastrointestinal hormones in adjuvant treatment of FC in chil⁃dren with yin⁃deficiency and qi stagnation syndrome,which has marked efficacy and deserves clinical promotion and application.