亚甲基四氢叶酸还原酶基因C677T多态性与亚洲人群多囊卵巢综合征风险相关性的Meta分析

Association between methylene tetrahydrofolate reductase gene C677T polymorphism and polycystic ovary syndrome risk in Asian population: a Meta-analysis

目的评估亚甲基四氢叶酸还原酶(MTHFR)C677T多态性与多囊卵巢综合征(PCOS)风险之间的相关性。方法系统搜索PubMed、EMBASE、万方和CNKI数据库,将截至2021年9月1日对14项已发表的亚洲受试者病例对照研究进行Meta分析。通过计算95%CI和OR评估其相关性。结果在4种遗传模型中,MTHFR C677T多态性与PCOS风险之间存在显著关联(T比C:OR=1.53,95%CI:1.21~1.94;TT+CT比CC:OR=1.47,95%CI:1.17~1.85;TT比CT+CC:OR=1.77,95%CI:1.28~2.43;TT比CC:OR=2.26,95%CI:1.36~3.14)。此外,对种族、对照来源、病因和基因型方法进行亚组分析发现,MTHFR C677T多态性与PCOS风险有显著相关性。结论MTHFR C677T多态性的T等位基因与亚洲人群PCOS风险增加相关,在中国人群中尤其显著。

Objective To evaluate the association of methylene trahydrofolate reductase(MTHFR) gene C677T polymorphism with polycystic ovary syndrome(PCOS) risk in Asian population. Method The PubMed, EMBASE, WanFang and the Chinese National Knowledge Infrastructure(CNKI) databases were searched from incipience to September 2021,fourteen studies were identified and included in the Meta-analysis. The crude odds ratios(OR) with 95% confidence intervals(95%CI) were calculated to evaluate the association between MTHFR gene C677T polymorphism and PCOS. Result The results of meta-analysis showed a significant association between the MTHFR C677T polymorphism and PCOS risk in four genetic variations(T vs. C: OR=1.53, 95%CI:1.21-1.94;TT+CT vs. CC: OR=1.47, 95%CI:1.17-1.85;TT vs. CT+CC: OR=1.77,95% CI:1.28-2.43;TT vs. CC :OR=2.26, 95% CI:1.36-3.14). Moreover, in subgroup analyses significant associations were observed when stratified by ethnicity, source of controls, etiology and genotype methods. Conclusion The Meta-analysis suggests that the T-allele of the MTHFR C677T polymorphism is associated with an increased risk of PCOS in the Asian population, especially significant in Chinese population.