摘要
细菌的异质性耐药是指不同亚群对抗生素的敏感性不同,这些耐药亚群可以在抗生素的存在下存活,影响治疗的效果。近年来,幽门螺杆菌(Helicobacter pylori,H.pylori)对抗生素的耐药率不断增加导致其根除治疗效果不佳。随着对异质性耐药了解的深入,部分研究提示异质性耐药的产生可能是导致H.pylori根治失败的重要原因之一。本文对H.pylori异质性耐药的相关文献进行梳理,就其可能的形成原因和现有的检测方法作一概述。
Bacteria heteroresistance to antibiotics refers to the different susceptibility for different subpopulations.The resistent subpopulations could survive in the presence of antibiotics and affect the efficacy of treatment.In recent years,the increasing resistance rates of Helicobacter pylori(H.pylori)to antibiotics have resulted in the poor efficacy for its eradication therapy.With the further understanding of heteroresistance,some studies have suggested that it may be one of the important factors leading to the failure of H.pylori eradication.In this paper,we combed the relevant literature on H.pylori heteroresistance to antibiotics and provided a review on the possible causes and available detection methods for it.
作者
任政宇
庆会国
贠建蔚
REN Zhengyu;QING Huiguo;YUN Jianwei(The Second Clinical Medical College,Lanzhou University,Lanzhou 730030;Department of Gastroenterology,the Second Hospital of Lanzhou University,China)
出处
《胃肠病学和肝病学杂志》
CAS
2022年第9期974-979,共6页
Chinese Journal of Gastroenterology and Hepatology
基金
甘肃省自然科学基金项目(21JR1RA131)
兰州大学第二医院萃英计划(临床拔尖技术研究项目:CY2021-BJ-A09)。
关键词
幽门螺杆菌
异质性耐药
研究进展
Helicobacter pylori
Heteroresistance
Research progress