摘要
目的探讨钾离子竞争性酸阻滞剂(potassium-competitive acid blocker,P-CAB)富马酸伏诺拉生替代质子泵抑制剂(proton pump inhibitor,PPI)治疗持续难治性幽门螺杆菌(Helicobacter pylori,H.pylori)感染的临床疗效。方法12例H.pylori感染慢性胃炎患者,男7例,女5例,年龄41~70岁,均给予PPI+铋剂+阿莫西林+克拉霉素或左氧氟沙星+呋喃唑酮等治疗2~3个疗程,H.pylori仍持续阳性2年以上。均给予富马酸伏诺拉生20 mg,1次/d,枸橼酸铋钾胶囊2粒,3次/d,左氧氟沙星0.5 g,2次/d,阿莫西林1.0 g,2次/d,用药2周。停药后1个月行^(13)C尿素呼气试验。结果12例患者^(13)C尿素呼气试验均呈阴性。结论富马酸伏诺拉生联合铋剂及抗生素有助于根治难治性H.pylori持续感染。
Objective To explore the clinical efficacy of potassium-competitive acid blocker(P-CAB)Vonoprazan fumarate instead of proton pump inhibitor(PPI)in the treatment of persistent refractory Helicobacter pylori(H.pylori)infection.Methods 12 patients with chronic gastritis infected by H.pylori,7 males and 5 females,aged 41-70 years old,were treated with PPI+Bismuth+Amoxicillin+Clarithromycin or Levofloxacin+Furazolidone etc.2-3 courses,H.pylori continued to be positive for more than 2 years.They were given Vonoprazan fumarate 20 mg,once a day,two Bismuth potassium citrate capsules 3 times a day,Levofloxacin 0.5 g,twice a day,and Amoxicillin 1.0 g,twice a day for 2 weeks.A ^(13)C-urea breath test was performed one month after the drug was stopped.Results The ^(13)C-urea breath test of 12 patients was negative.Conclusion Vonoprazan fumarate combined with Bismuth and antibiotics can help cure persistent infection of refractory H.pylori.
作者
刘晓菲
王静
樊贞瑜
李俊
田成
张亚军
程计林
LIU Xiaofei;WANG Jing;FAN Zhenyu;LI Jun;TIAN Cheng;ZHANG Yajun;CHENG Jilin(Department of Gastroenterology,Shanghai(Affiliated to Fudan University)Public Health Clinical Center,Shanghai 201508;Department of Gastroenterology,Tianjin Second People′s Hospital,China)
出处
《胃肠病学和肝病学杂志》
CAS
2022年第9期990-991,共2页
Chinese Journal of Gastroenterology and Hepatology
基金
中国肝炎防治基金会天晴肝病研究基金(KY-QT-2017-01)。