链霉蛋白酶颗粒联合二甲硅油散在老年人无痛胃镜检查中的应用

Application of Pronase Granules Combined with Simethicone Powder in Painless Gastroscopy in the Elderly

目的:探讨链霉蛋白酶颗粒联合二甲硅油散在老年人无痛胃镜检查中的应用价值。方法:选取2020年8月—2022年1月本院进行无痛胃镜检查的老年患者88例作为研究对象,根据1∶1简单分配原则把患者分为联合组与对照组,各44例。对照组在无痛胃镜检查前30 min口服西甲硅油散,联合组在无痛胃镜检查前30 min口服链霉蛋白酶颗粒联合二甲硅油散,比较两组胃镜操作时间与丙泊酚使用剂量、胃肠道清洁程度分级、不同部位胃黏膜可见度评分、不良反应发生率及早期胃癌检出率。结果:联合组胃镜操作时间短于对照组,丙泊酚使用剂量少于对照组(P<0.05);联合组胃肠道清洁程度分级优于对照组(P<0.05);联合组不同部位胃黏膜可见度评分低于对照组(P<0.05);联合组不良反应发生率为2.3%,低于对照组的22.7%(P<0.05);联合组早期胃癌检出率高于对照组(P<0.05)。结论:链霉蛋白酶颗粒联合二甲硅油散在老年人无痛胃镜检查中能提高早期胃癌的检出率,减少胃镜操作时间与丙泊酚使用剂量,提高胃肠道清洁程度,降低不良反应发生率,提高胃黏膜可见度评分。

Objective:To explore the application value of pronase granules combined with simethicone powder in painless gastroscopy in the elderly.Methods:A total of 88 elderly patients who underwent painless gastroscopy in our hospital from August 2020 to January 2022 were selected as the research subjects,and the patients were divided into the combined group and the control group according to the 1:1 simple allocation principle,with 44 cases in each.The control group was given oral simethicone powder 30 minutes before painless gastroscopy,and the combination group was given pronase granules combined with simethicone powder 30 minutes before painless gastroscopy.The operation time of gastroscopy,the dose of propofol,the grade of gastrointestinal cleanliness,the visibility score of gastric mucosa in different parts,the incidence of adverse reactions and the detection rate of early gastric cancer were compared between the two groups.Results:The operation time of gastroscope in the combined group was shorter than that in the control group,and the dosage of propofol was less than that in the control group(P<0.05);the grade of gastrointestinal cleanliness in the combined group was better than that in the control group(P<0.05);the incidence of adverse reactions in the combination group was 2.3%,which was lower than 22.7%in the control group(P<0.05);the detection rate of early gastric cancer in the combination group was higher than that in the control group(P<0.05).Conclusion:Pronase granules combined with simethicone powder in the elderly painless gastroscopy can improve the detection rate of early gastric cancer,reduce the operation time of gastroscopy and the dosage of propofol,improve the cleanliness of the gastrointestinal tract,reduce the incidence of adverse reactions,and improve the gastric mucosal visibility score.