国外百日咳疫苗免疫原性与保护效果的关系研究进展

The association of immunogenicity with effectiveness of foreign pertussis vaccine:a literature review

全细胞百日咳疫苗向无细胞百日咳疫苗转换后,越来越多疫苗覆盖率较高的国家出现“百日咳再现”,报告百日咳病例增加且向青少年和成人转移。疫苗的转换被认为是百日咳发病率增高的原因之一,疫苗抗原的种类和数量、生产工艺和佐剂的差异可能对疫苗的质量和效果产生影响。本文对国外百日咳疫苗抗原成分及其免疫机制、疫苗免疫原性与保护效果的关系进行综述,为优化现有百日咳疫苗免疫策略和新疫苗研发提供支持。

Since pertussis vaccine was changed from whole-cell to acellular vaccine,a"pertussis resurgence"has been seen in more and more countries that have high vaccine coverage.In these resurgences,pertussis reports increased in frequency and shifted from young children to adolescents and adults.Changing from whole-cell to acellular pertussis vaccine is considered to be one of the causes of the increase in pertussis.Type and quantity of vaccine antigens,production processes,and adjuvants may affect the quality and effectiveness of vaccines.In this article,we review antigenic components of foreign pertussis vaccines,immune mechanisms of vaccine antigens,and the association of vaccine immunogenicity with vaccine effectiveness in order to provide references for optimizing current pertussis immunization strategies and developing new vaccines.