细胞衰老在骨关节炎中作用的研究进展

Research progress on the role of cellular senescence in osteoarthritis

骨关节炎(osteoarthritis, OA)是一种引起关节软骨不可逆的进行性破坏的退行性疾病,但目前尚无有效的方法来延缓OA的进展。近年来,越来越多证据表明OA的发生、发展与关节组织中衰老细胞数量的增加相关,衰老细胞及其衰老相关分泌表型(senescence-associated secretory phenotype, SASP)在软骨退变和OA中发挥重要作用,靶向清除衰老细胞可以阻止关节软骨退变和OA进展。鉴于细胞衰老在OA中的重要作用,本文就细胞衰老与OA的因果关系,细胞衰老导致OA发生、发展的潜在细胞分子机制,以及靶向清除衰老细胞治疗OA的相关进展作一综述。

Osteoarthritis(OA) is a degenerative disease caused by irreversible and progressive destruction of articular cartilage. However, there is no effective method to delay the progression of OA. In recent years, more and more evidences show that the occurrence and development of OA is correlated with the increase of senescent cells in joint tissue, and senescent cells and their senescent associated secretory phenotype(SASP) have been implicated in cartilage degeneration and OA. Targeted clearance of senescent cells can prevent articular cartilage degeneration and OA progression. In view of the important role of cell senescence in OA, this paper reviews the progress of the causal relationship between cell senescence and OA, the potential cellular and molecular mechanisms of cell senescence leading to the occurrence and development of OA, as well as targeted removal of senescent cells in OA therapy.