深髓静脉与脑小血管病研究进展

Advances in the research of deep medullary veins and cerebral small vessel disease

脑小血管病(CVSD)是一类常见的疾病。虽然CVSD主要影响脑动脉小血管的病理,但脑实质的小静脉逐渐被关注,特别是引流深部白质的深髓静脉(DMVs)。随着3.0T磁共振,特别是磁敏感加权成像(SWI)的发展,使得DMVs的结构可以清晰显现。该文综述了DMVs在CVSD发展中的作用。DMVs可能参与了脑小血管病的病理过程,重视DMVs的影像学表现可以为疾病的发展和预后提供更多信息。DMVs与CVSD神经影像学标志物之间的关系提示了小静脉在与年龄相关的神经退行性过程中的潜在作用,值得进一步研究。

Cerebral small vessel disease(CSVD)are prevalent.Although arteriolar disease has been implicated in their pathogenesis,venous pathology warrants consideration,especially the deep medullary veins(DMVs)that drain deep white matter.with increased use of 3-T imaging such as susceptibility weighted imaging(SWI)that can be used to visualize venous structures,understanding of the structure of venous anatomy has become feasible.In this review article,we will describe CVSD in which the DMVs play a major role in disease development.DMVs involved pathomechanism may participate in the CSVD development.Attach importance to DMVs radiological profile in CSVD will provide more neuroimaging information for diagnosis and prognosis.the significant association between DMVs and CVSD neruoimage markers suggested the potential role of venules in age-related neurodegenerative process,which deserves further investigation.