摘要
合成了一个萘酰亚胺衍生物(Npd)荧光探针并鉴定了其化学结构。Npd表现出分子内电荷转移(ICT)和聚集诱导发光(AIE)性质。该化合物可以在水相中识别苦味酸(2,4,6-三硝基苯酚,PA),检测限为2.09×10^(-6)mol/L。作用机制为PA的质子转移到Npd,有效地阻断了其ICT发射,使荧光发生显著猝灭。另外,Npd细胞毒性较低,可做成试纸对PA进行快速检测。
A naphthalimide derivative(Npd)was synthesized and characterized.Npd presented intramolecular charge transfer(ICT)emission and aggregation-induced emission(AIE).It could be used to detect picronitric acid(2,4,6-trinitrophenol,PA)in aqueous phase,and the calculated limit detection was 2.09×10^(-6)mol/L.The mechanism for sensing PA was investigated using^(1)H NMR,the proton transfered from PA to Npd and blocked the ICT emission,and caused the fluorescence remarkably to be quenched.Further,Npd showed low cytotoxicity and could be made into test strips for rapid PA detection.
作者
龚慧媛
穆叶舒
洪琛
罗稳
王超杰
GONG Huiyuan;MU Yeshu;HONG Chen;LUO Wen;WANG Chaojie(Key Laboratory of Natural Medicine and Immuno-Engineering,Henan University,Kaifeng 475004,Henan,China;School of Pharmacy,Henan University,Kaifeng 475004,Henan,China;Huaihe Hospital,Henan University,Kaifeng 475004,Henan,China)
出处
《化学研究》
CAS
2022年第5期444-452,共9页
Chemical Research
关键词
萘酰亚胺
荧光探针
聚集诱导发光
苦味酸
Naphthalimide
fluorescent probe
Aggregation-induced emission
picronitric acid
