一种新型水凝胶的制备及影响因素

Preparation of A Novel Type of Hydrogeland and Its Influencing Factors

本研究设计制备石胆酸聚吡咯聚多巴胺新型水凝胶,并优化制备路径。通过吸附在自组装石胆酸纳米管交联网络上的吡咯的聚合,可以简单有效地进行聚吡咯纳米管水凝胶的模板化制备。同时采用“粘性”生物分子多巴胺对聚吡咯进行功能化,增强其在水中的分散性和稳定性,可以在不影响聚吡咯生物相容性的前提下改善其粘附性。实验结果显示:水浴超声更有利于吡咯在石胆酸模板上均匀的聚集;多巴胺能够改善聚吡咯水凝胶的力学性能,有利于聚吡咯的成胶,并且多巴胺和吡咯的最优摩尔配比为0.05∶1~0.1∶1;不同浓度的吡咯对该新型水凝胶的机械性能和形态有较大的影响。综上所述,以自组装石胆酸纳米管作为吡咯聚合的模板,可以实现聚吡咯纳米管水凝胶的简单有效制备。

This study designs and prepares a novel hydrogel of lithocholic acid,polypyrrole and polydopamine,and optimizes its preparation path as well.Polypyrrole nanotube hydrogel can be prepared easily and effectively by the polymerization of pyrrole absorbed on interconnected networks of self-assembled lithocholic acid nanotubes.Dopamine as a“sticky”biomolecule is employed to functionalize polypyrrole and enhance dispersion and stability in water,improving the adhesion without affecting the biocompatibility.The experiment results show that water-bath ultrasound is more conducive to the uniform aggregation of pyrrole on the template of lithocholic acid;Dopamine can improve the mechanical properties of polypyrrole hydrogel and contribute to the gelation of polypyrrole;moreover,the optimal molar ratio of Dopamine and pyrrole is 0.05∶1~0.1∶1;and the mechanical properties and morphology of the hydrogel are significantly affected by different concentrations of pyrrole.In summary,easy and effective preparation of polypyrrole nanotubes hydrogel can be achieved by adopting self-assembled lithocholic acid nanotubes as a template for pyrrole polymerization.