微小RNA在原发性胆汁性胆管炎发病机制和诊疗中的作用

Role of microRNA in the pathogenesis,diagnosis and treatment of primary biliary cholangitis

原发性胆汁性胆管炎(primary biliary cholangitis, PBC)是一种慢性胆汁淤积性肝病,其具体病因尚不明确。研究表明PBC中存在表观遗传异常,尤其是微小RNA(micro RNA, miRNA)的改变,mi RNA可参与PBC的发病过程,并在诊断、疾病进展、疗效预测中作为潜在靶点发挥生物标志物作用。本文将综述mi RNA在PBC机制调控、诊疗中作用的研究进展,为PBC相关mi RNA的研究提供思路。

Primary biliary cholangitis(PBC) is a chronic cholestatic liver disease of unknown etiology. Studies have shown that there are epigenetic abnormalities in PBC, especially the changes of microRNA(miRNA), which can participate in the pathogenesis of PBC and play a marker role as a potential target in diagnosis, disease progression, and efficacy prediction. This article reviewed the progress of miRNAs in PBC mechanism regulation, diagnosis and treatment, and provided ideas for the study of PBC-related miRNAs.