CXCL13/CXCR5信号通路在HBV感染中的研究进展及临床意义

Progress and clinical significance of CXCL13/CXCR5 signaling pathway in HBV infection

HBV感染是人类面临的重大公共卫生问题,尽管有效的抗病毒治疗可延缓疾病进展,但仍很难实现“临床治愈”的目标。机体的适应性免疫应答在控制和清除病毒的过程中发挥关键作用。新近研究发现,趋化因子配体13(chemokine ligand 13, CXCL13)/趋化因子受体5(chemokine receptor 5, CXCR5)信号通路在调节HBV特异性体液免疫和细胞免疫应答中均发挥重要作用,这或是探索慢性乙型肝炎“临床治愈”的重要靶点。本文就CXCL13/CXCR5信号通路的生物学特点及其在HBV感染中的临床研究进展及意义进行综述。

HBV infection is a major public health problem affecting the world. Though effective antiviral therapy can delay disease progression, achieving a “clinical cure” is still difficult. The adaptive immune response plays a key role in controlling and eliminating the virus.Recently, some studies have found that the chemokine ligand 13(CXCL13) and its receptor chemokine receptor 5(CXCR5) signaling pathway plays an important role in the regulation of HBV-specific humoral and cellular immune response, which may be an important target for exploring the “clinical cure” of chronic hepatitis B. In this paper, we summarized the biological characteristics of CXCL13/CXCR5 signaling pathway and its clinical research progress and significance in HBV infection.