金纳米团簇在生物成像中的应用研究

Research Progress on Application of Gold Nanoclusters in Biological Imaging

金纳米团簇作为一种新型发光的纳米材料,其粒子直径通常小于2 nm,接近电子费米波长,从而产生类似分子的性质,包括离散的电子态和与尺寸密切相关的荧光。由于金簇具有超小尺寸,优良的荧光性能和生物相容性等特点,故多次被发展为荧光传感器,应用于生物成像、传感、环境监测等方面。本文将对金簇与尺寸相关的发光原理、合成方法,以及作为纳米探针应用于生物成像研究进行综述,并对金簇的今后发展趋势做简要展望。

As the new type of luminescent nanomaterials,gold nanoclusters are usually less than 2 nm in diameter,which is close to the electronic Fermi wavelength,resulting in similar molecular properties,including discrete electronic states and size dependent fluorescence.Due to the characteristics of ultra-small size,excellent fluorescence performance and biocompatibility,gold nanoclusters had been developed as fluorescence probes many times,which were used in biological imaging,sensing,environment monitoring,and so on.The size-dependent luminescent principle,synthesis methods and application of gold nanoclusters as nanoprobes in biological imaging were reviewed,and the future trend of gold nanoclusters was briefly prospected.