血清维生素B_(12)水平与抑郁状态的相关性分析

Analysis of The Correlation Between Serum Vitamin B_(12) Levels and Depressive Status

目的:分析血清维生素B_(12)水平与抑郁状态的相关性。方法:收集2020年3月—2021年12月在我院精神科就诊的100例首次诊断为抑郁状态的患者和同期收集的100例健康体检者为研究对象。抑郁状态的诊断依据HAMD,将得分≥7分的患者记为病例组、<7分的患者为对照组。采用自制问卷收集患者一般情况信息,收集空腹静脉血检测血清维生素B_(12)、同型半胱氨酸(Hcy)、血红蛋白(HGB)、白蛋白(ALB)水平,比较抑郁状态者与正常者血清上述血清指标差异,分析抑郁状态的可能危险因素。结果:存在抑郁状态的患者存在睡眠障碍者更多,且更缺乏规律体育锻炼(P<0.05),抑郁状态患者血清维生素B_(12)水平显著低于对照组患者[(278.94±96.83)vs(386.35±103.28)]pg/mL,而血清Hcy水平高于对照组[(15.96±4.26)vs(11.63±5.21)]μmol/L(均有P<0.05)。抑郁状态危险因素的多因素分析结果显示,血清低维生素B_(12)水平、高Hcy水平及存在睡眠障碍是存在抑郁状态的明确危险因素,且血清维生素B_(12)水平与抑郁状态呈显著负相关,血清Hcy水平与抑郁状态呈显著正相关。结论:血清维生素B_(12)和Hcy水平与抑郁状态密切相关,正常人应注意膳食维生素B_(12)的摄入,调整睡眠状况,监测血清维生素B_(12)、Hcy水平,以降低抑郁症的发生风险。

Objective To analyze the correlation between serum vitamin B_(12) levels and depressive status.Method Totally 100 patients with a first diagnosis of depressive status who attended psychiatry department from March 2020 to December 2021 and 100 health checkups collected during the same period were collected for the study.The diagnosis of depressive status was based on the HAMD,and patients with a score≥7 were recorded as the case group and those with a score<7 as the control group.A self-administered questionnaire was used to collect information on the general condition of the patients,and fasting venous blood was collected to measure serum levels of vitamin B_(12),homocysteine(Hcy),hemoglobin(HGB)and albumin(ALB),and to compare the differences between the above serum indicators in depressed and normal patients,and to analyze the possible risk factors of depression.Result Patients with depressive states had more sleep disturbances and lacked regular physical activity(P<0.05),and serum vitamin B_(12) levels were significantly lower in patients with depressive states than in control patients[(278.94±96.83)vs(386.35±103.28)]pg/mL,while serum Hcy levels were higher than in control patients[(15.96±4.26)vs(11.63±5.21)]μmol/L,all with P<0.05.The results of multifactorial analysis of risk factors for depressive status showed that low serum vitamin B_(12) levels,high Hcy levels and the presence of sleep disorders were clear risk factors for the presence of depressive status,and serum vitamin B_(12) levels were significantly negatively associated with depressive status,and serum Hcy levels were significantly positively associated with depressive status.Conclusion Serum vitamin B_(12) and Hcy levels are closely related to depressive status,and normal individuals should pay attention to dietary vitamin B_(12) intake,adjust sleep status,and monitor serum vitamin B_(12) and Hcy levels to reduce the risk of depression.