心房颤动患者血清转化生长因子β2及半乳糖凝集素-2的表达及临床意义

Expression and clinical significance of serum galactose lectin-2 and transforming growth factor-β2 in patients with atrial fibrillation

目的:探讨血清转化生长因子β2(TGF-β2)及半乳糖凝集素-2(Galectin-2)在心房颤动患者中的表达情况及临床意义。方法:选取2019年1~6月蚌埠医学院第一附属医院心内科住院患者150例,其中阵发性心房颤动组84例,持续性心房颤动组66例,以及同时期入院检查排除心房颤动的窦性心律患者120例作为对照组,入院后完善血常规、生化常规以及心脏超声形态学检查。另外,采用ELISA法及Western Blot检测各组受试者血清及外周血单个核细胞(PBMC)中TGF-β2和Galectin-2水平,分析两者在不同分组间的差异及临床意义;应用Pearson相关性分析进一步检验TGF-β2、Galectin-2与左心房舒张末期内径(LAD)的相关性;通过二元Logistics回归分析的方式,得出影响心房颤动的因素。结果:与对照组相比,心房颤动组患者年龄及LAD明显升高,差异具有统计学意义(P<0.05);持续性房颤组患者血清中TGF-β2和Galectin-2浓度相较于阵发性房颤组及对照组均明显增高,差异具有统计学意义(P<0.05),对照组相较于阵发性房颤组明显下降,差异具有统计学意义(P<0.05);Pearson相关性分析显示在实验组中TGF-β2和Galectin-2浓度与LAD大小呈正相关(P<0.05);二元logistics回归分析显示TGF-β2、Galectin-2、LAD是房颤的危险因素(P<0.05)。结论:TGF-β2、Galectin-2与房颤的发生、发展有着密切关系。TGF-β2与Galectin-2之间且二者与LAD间均呈正相关,三者在房颤患者心房炎性纤维化的发生与进展中具有协同作用,共同促进心房的机械重构及电重构,并可作为评估房颤发生发展的危险因素。

Objective:To investigate the expression of serum transforming growth factorβ2(TGF-β2)and galectin-2(Galectin-2)in patients with atrial fibrillation and its clinical significance.Methods:A total of 150 inpatients in the Department of Cardiology of the First Affiliated Hospital of Bengbu Medical College from January 2019 to June 2019 were selected,including 84 patients in the paroxysmal atrial fibrillation group,66 patients in the persistent atrial fibrillation group,and 120 patients with sinus rhythm excluding atrial fibrillation who were hospitalized during the same period were selected as the control group.Blood routine,biochemical routine and cardiac ultrasonic morphological examination were improved after admission.In addition,the serum levels of TGF-β2 and Galectin-2 in each group were detected by Elisa and Western Blot,and the differences and clinical significance of TGF-β2 and Galectin-2 in different groups were statistically analyzed.The correlation between TGF-β2,Galectin-2 and left atrial end-diastolic diameter(LAD)was further determined by Pearson correlation analysis.By means of binary logistics regression analysis,the factors affecting atrial fibrillation were obtained.Results:Compared with the control group,age and LAD in atrial fibrillation group were significantly increased(P<0.05).The serum concentrations of TGF-β2 and galectin-2 in persistent af group were significantly increased compared with those in paroxysmal af group and control group(P<0.05),while those in control group were significantly decreased compared with paroxysmal AF group(P<0.05).Pearson correlation analysis showed that TGF-β2and Galectin-2 concentrations were significantly positively correlated with LAD size in the experimental group(P<0.05).Binary logistic regression analysis showed that TGF-β2,galectin-2 and LAD were risk factors for atrial fibrillation(P<0.05).Conclusion:TGF-β2 and Galectin-2 are closely related to the occurrence and development of atrial fibrillation.Both TGF-β2 and Galectin-2 were positively correlated with LAD.The three have a synergistic effect on the occurrence and progression of atrial inflammatory fibrosis in patients with ATRIAL fibrillation,jointly promoting mechanical and electrical remodeling of atrial,and can be used as risk factors to evaluate the occurrence and progression of atrial fibrillation.