lncRNA与COPD发病机制的相关研究进展

Research progress on the correlation between lnc RNA and the pathogenesis of COPD

慢性阻塞性肺疾病作为一种发病率及致死率较高的常见慢性疾病,其早期预防、诊治可有效降低其发病率,改善预后,减轻患者家庭经济负担。随着分子生物学研究的深入,lncRNA成为近几年研究热点,其参与疾病的发生、发展及转归,为疾病研究提供新的方向。本文就lncRNA生物学特性及其与慢性阻塞性肺疾病的诱因、病理变化及治疗药物间联系的研究进展作一综述。

Chronic obstructive pulmonary disease is a common chronic disease with high morbidity and mortality.Early prevention,diagnosis and treatment of chronic obstructive pulmonary disease can effectively reduce its morbidity,improve prognosis,and reduce the economic burden of patients’families.With the deepening of molecular biology research,lncRNAs have become a research hotspot in recent years.They are involved in the occurrence,development and prognosis of diseases,providing new directions for disease research.This article reviews the research progress on the biological characteristics of lncRNAs and their association with the causes,pathological changes and therapeutic drugs of chronic obstructive pulmonary disease.