多巴胺能与胆碱能通路在近视发生发展中的作用研究进展

Research progress of the dopaminergic and cholinergic signaling pathways in myopia

近视已成为全球范围的公共卫生问题,但其发病机制尚未完全阐明。多巴胺和乙酰胆碱作为视网膜上重要的神经递质,通过与其对应受体结合发挥作用,在实验性近视的形成和抑制中具有重要意义。相关信号通路在近视发生发展中的具体作用机制也备受关注。大多数研究支持多巴胺及乙酰胆碱受体拮抗剂一定程度上可抑制实验性近视的发展;药理学实验进一步揭示,两条信号通路之间相互交叉、相互影响,可能存在共同的作用位点。本文就近年来多巴胺能通路和胆碱能通路及其二者的联系在近视领域的研究现状进行简要综述,旨在为进一步探索近视的发病机制以及近视防治提供参考。

·Myopia has become a global public health concern.However,its mechanism remains unclear.Dopamine and acetylcholine,as important neurotransmitters in retina,play a critical role in the formation and inhibition of experimental myopia by binding to specific receptors respectively.Simultaneously,the mechanisms of related signaling pathways during myopia have attracted much attention.Most studies have identified that dopamine and acetylcholine receptor antagonists could inhibit the development of experimental myopiato some extent.Furthermore,pharmacological experiments have suggested that the two signaling pathways cross and influence each other,and there may be common mediators.In this paper,we briefly reviewed the recent researches on dopaminergic and cholinergic signaling pathways and their association during myopia,to provide references for further insights into pathogenesis as well as the prevention and treatment of myopia.