达比加群酯专利技术分析

Analysis of dabigatran ester patent technology

达比加群酯是一种抗凝血药物,自首次报道以来,其相关的专利申请量逐年递增,涉及产品的结构改进、晶型以及合成方法等诸多方面。为分析达比加群酯相关技术专利申请状况与合成路线,本文通过在专利数据库中进行全面检索与数据分析,筛选出最具有代表性的重要专利,尤其筛选出涉及合成路线的最核心专利,最终综述了达比加群酯的专利申请情况,对具有代表性的主要合成路线的演进进行了整理,可为相关领域的科研人员提供参考。

Dabigatran ester is an anticoagulant drug. Since it was first reported,its related patent applications have increased year by year,involving many aspects such as product structure improvement,crystal form and synthesis method. In order to analyze the patent application status and synthesis route of dabigatran ester related technology,this paper screened out the most representative important patents,especially the core patents related to the synthesis route,through comprehensive search and data analysis in the patent database,Finally,the patent applications of dabigatran esters are summarized,and the evolution of representative main synthesis routes is sorted out,which can provide reference for researchers in related fields.