舍格伦综合征唾液腺中自噬现象的研究进展

Role of autophagy in salivary glands of Sjögren’s syndrome

原发性舍格伦综合征(pSS)是一种以外分泌腺大量破坏引起口干、眼干等症状并可累及全身多系统为特征的自身免疫性疾病。自噬参与机体固有和适应性免疫反应,自噬异常可能打破免疫系统稳态,参与pSS的发生发展。本文从自噬与正常唾液腺的稳态与应激,自噬相关蛋白在pSS腺体的异常表达,pSS中自噬与固有免疫及适应性免疫,自噬与pSS的药物治疗4个方面,对自噬与pSS发生发展的关系作一综述,为深入研究自噬在pSS中的作用机制,预防和治疗pSS提供新的方向与思路。

Primary Sjögren’s syndrome is an autoimmune disease characterized by the destruction of exocrine glands,causing dry mouth,dry eyes,and multiple systemic manifestations.Autophagy is involved in the innate and adaptive immune responses.Autophagy dysregulation may break the immune homeostasis and participate in the incidence and development of pSS.Here,we reviewed the relationship between autophagy and pSS from four aspects:the role of autophagy in the homeostasis and stress responses of salivary glands,the abnormal expression of autophagy-related proteins(ATG)in the pSS glands,the autophagy in innate immunity and adaptive immunity in pSS,and drug therapy aiming at autophagy of pSS.We provided new directions and ideas for further study on the mechanism of autophagy in pSS and ultimately contribute to prevention and treatment of pSS.