强化降脂治疗急性脑梗死的疗效及对血清炎症因子的影响观察

Efficacy of intensive lipid-lowering therapy in the treatment of acute cerebral infarction and its influence on serum inflammatory factors

目的探讨强化降脂治疗急性脑梗死患者的临床疗效及对血清炎症因子的影响。方法72例急性脑梗死患者,随机分为常规组和研究组,各36例。常规组选择常规疗法+常规剂量阿托伐他汀钙片治疗,研究组选择常规疗法+强化降脂方法治疗。比较两组患者治疗效果及治疗前后血脂指标[甘油三酯(TG)、总胆固醇(TC)]、血清炎症因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、超敏C反应蛋白(hs-CRP)]水平。结果研究组治疗总有效率97.22%高于常规组的75.00%,差异具有统计学意义(P<0.05)。治疗前,研究组TG(1.83±0.43)mmol/L、TC(6.61±0.92)mmol/L与常规组的(1.79±0.37)、(6.69±0.96)mmol/L比较,差异无统计学意义(P>0.05);治疗后,研究组TG(1.22±0.35)mmol/L、TC(3.52±0.49)mmol/L均低于常规组的(1.55±0.62)、(4.69±0.72)mmol/L,差异具有统计学意义(P<0.05)。治疗前,研究组IL-6(14.81±2.51)μg/L、IL-8(114.82±5.59)pg/ml及hs-CRP(9.52±1.35)mg/L与常规组的(14.79±2.43)μg/L、(114.77±5.63)pg/ml及(9.63±1.43)mg/L比较,差异无统计学意义(P>0.05);治疗后,研究组IL-6(6.55±1.53)μg/L、IL-8(48.82±10.53)pg/ml及hs-CRP(1.79±0.32)mg/L均低于常规组的(9.72±2.59)μg/L、(69.72±5.69)pg/ml及(3.93±0.79)mg/L,差异具有统计学意义(P<0.05)。结论对急性脑梗死患者应用强化降脂治疗可明显提高临床疗效,有效降低血清炎症因子及血脂水平,值得临床推广。

Objective To discuss the clinical efficacy of intensive lipid-lowering therapy in the treatment of acute cerebral infarction and its influence on serum inflammatory factors.Methods A total of 72 patients with acute cerebral infarction were randomly divided into conventional group and research group,with 36 cases in each group.The conventional group received conventional therapy+conventional dose of atorvastatin calcium tablets,and the research group received conventional therapy+intensive lipid-lowering therapy.Both groups were compared in terms of therapeutic effect,blood lipid indexes[triglyceride(TG),total cholesterol(TC)],serum inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8)and high-sensitivity C-reactive protein(hs-CRP)]before and after treatment.Results The total effective rate 97.22%of the research group was higher than 75.00%of the conventional group,and the difference was statistically significant(P<0.05).Before treatment,the TG and TC were(1.83±0.43)mmol/L and(6.61±0.92)mmol/L in the research group,and the differences were not statistically significant when compared with(1.79±0.37)and(6.69±0.96)mmol/L in the conventional group(P>0.05).After treatment,the TG(1.22±0.35)mmol/L and TC(3.52±0.49)mmol/L in the research group were lower than(1.55±0.62)and(4.69±0.72)mmol/L in the conventional group,and the differences were statistically significant(P<0.05).Before treatment,the IL-6,IL-8 and hs-CRP were(14.81±2.51)μg/L,(114.82±5.59)pg/ml and(9.52±1.35)mg/L in the research group,which were not statistically significant compared with(14.79±2.43)μg/L,(114.77±5.63)pg/ml and(9.63±1.43)mg/L in the conventional group(P>0.05).After treatment,the IL-6(6.55±1.53)μg/L,IL-8(48.82±10.53)pg/ml and hs-CRP(1.79±0.32)mg/L in the research group were lower than(9.72±2.59)μg/L,(69.72±5.69)pg/ml and(3.93±0.79)mg/L in the conventional group,and the differences were statistically significant(P<0.05).Conclusion Intensive lipid-lowering therapy can obviously improve the clinical efficacy of patients with acute cerebral infarction,and effectively lower the levels of serum inflammatory factors and blood lipids,which is worthy of clinical promotion.