缩宫素、米索前列醇及卡前列素氨丁三醇联合用药治疗产后出血的临床效果分析

Clinical effect of the combination of oxytocin,misoprostol and carboprost tromethamine in the treatment of postpartum hemorrhage

目的分析缩宫素、米索前列醇及卡前列素氨丁三醇联合用药治疗产后出血的临床效果。方法84例产后出血患者,随机分为参照组及观察组,每组42例。参照组实行缩宫素单药治疗,观察组实行缩宫素、米索前列醇及卡前列素氨丁三醇联合用药治疗。对比两组患者产后出血量、出血时间、住院时间、不良反应发生情况及治疗效果。结果观察组产后2 h出血量(260.81±12.94)ml、产后24 h出血量(297.41±17.30)ml少于参照组的(548.35±13.01)、(564.48±16.45)ml,出血时间(28.51±5.80)h以及住院时间(6.42±2.30)d短于参照组的(37.15±4.15)h、(9.24±2.52)d,差异具有统计学意义(P<0.05)。两组不良反应发生率对比差异无统计学意义(P>0.05)。观察组治疗总有效率95.24%(40/42)高于参照组的73.81%(31//42),差异具有统计学意义(P<0.05)。结论对于产后出血患者,联合用药效果明显优于单一用药,能够有效减少患者的出血量以及缩短出血时间,安全性高,治疗效果明显,值得临床广泛推广应用。

Objective To analyze the clinical effect of the combination of oxytocin,misoprostol and carboprost tromethamine in the treatment of postpartum hemorrhage.Methods A total of 84 patients with postpartum hemorrhage were randomly divided into reference group and observation group,with 42 cases in each group.The reference group was treated with oxytocin monotherapy,and the observation group was treated with combined treatment of oxytocin,misoprostol and carboprost tromethamine.The postpartum hemorrhage,bleeding time,hospitalization time,occurrence of adverse reactions and therapeutic effects were compared between the two groups.Results The 2 h postpartum hemorrhage(260.81±12.94)ml and 24 h postpartum hemorrhage(297.41±17.30)ml in the observation group were less than(548.35±13.01)and(564.48±16.45)ml in the reference group;the bleeding time(28.51±5.80)h and hospitalization time(6.42±2.30)d in the observation group were shorter than(37.15±4.15)h and(9.24±2.52)d in the reference group;all the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).The total effective rate 95.24%(40/42)of the observation group was higher than 73.81%(31/42)of the reference group,and the difference was statistically significant(P<0.05).Conclusion In patients with postpartum hemorrhage,the effect of combined medication is significantly better than that of single medication,which can effectively reduce the blood loss and shorten the bleeding time of patients,with high safety and obvious therapeutic effect,and is worthy of widespread clinical promotion and application.