幽门螺杆菌与胃肠及胃肠外疾病关系的研究进展

Advances in the relationship between Helicobacter pylori and gastrointestinal and extra-gastrointestinal diseases

幽门螺杆菌(Hp)在全世界约50%的人口中存在,在发展中国家感染率达70%以上,已经证实慢性胃炎、胃十二指肠溃疡、胃癌、胃黏膜相关淋巴组织(MALT)淋巴瘤等疾病与Hp感染有关,Hp感染引起的胃肠外疾病目前也是一个研究热点,其机制可能涉及炎性反应、自身免疫等多方面。该文就Hp感染与部分胃肠疾病、胃肠外疾病的关系及其可能的机制进行综述,以期为临床诊治及早期预防提供参考。

Helicobacter pylori(Hp)exists in about 50%of the world’s population,and the infection rate in developing countries reaches more than 70%.It has been confirmed that chronic gastritis,gastroduodenal ulcer,gastric cancer,gastric mucosa-associated lymphoid tissue(MALT)lymphoma and other diseases are related to Hp infection.Extra-gastrointestinal diseases caused by Hp infection are also a research hotspot at present,and the mechanism may involve inflammation,autoimmunity,and other aspects.This article summarizes the relationship between Hp infection and some gastrointestinal diseases,extra-gastrointestinal diseases,and its possible mechanisms,and provides references for clinical diagnosis and treatment and early prevention.