脂质运载蛋白2在肝脏疾病发生发展中的作用

Role of lipocalin-2 in the development and progression of liver diseases

脂质运载蛋白2(LCN2)最初是从感染猴空泡病毒40的小鼠肾细胞培养物中纯化得到的一种分泌糖蛋白,在炎症期间对细胞稳态控制以及应对细胞应激或损伤的反应中发挥着关键作用,被认为是风湿病、癌症、肝脏疾病和炎症性疾病的一种潜在的生物标志物。已有研究表明,LCN2在肝实质细胞和非实质细胞中表达并分泌入血,与急性肝损伤、肝硬化、病毒性肝炎、酒精性肝病、非酒精性脂肪性肝病以及肝细胞癌等的发生发展密切相关。本文总结了LCN2与肝脏疾病发病机制相关的动物实验和临床研究,以期为肝脏疾病的防治提供新思路和治疗靶点。

Lipocalin-2(LCN2)is a secreted glycoprotein originally purified from mouse kidney cells infected with simian virus 40 and plays a key role in the control of cellular homeostasis during inflammation and the response to cellular stress or injury,and it is considered a potential biomarker for rheumatic diseases,cancer,liver diseases,and inflammatory diseases.Studies have shown that LCN2 is expressed in hepatic parenchymal and nonparenchymal cells and is secreted into the bloodstream,and it is closely associated with the development and progression of acute liver injury,liver cirrhosis,viral hepatitis,alcoholic liver disease,nonalcoholic fatty liver disease,and hepatocellular carcinoma.This article summarizes the animal experiments and clinical studies on the association of LCN2 with the pathogenesis of liver diseases,in order to provide new ideas and therapeutic targets for the prevention and treatment of liver diseases.