管径连续变化的锥形机织人工血管的制备及血液流动行为仿真评价

Preparation and blood flow behavior evaluation of CVCWvascular grafts

为分析管径连续变化的锥形机织人工血管(CVCW管)的管壁结构对流体流动行为的影响,本文首先基于仿生化设计的优越性,设计并制备了不同组织结构和锥度角的9种规格的CVCW试样,测试各试样的厚度、孔隙率和渗透性等管壁结构参数和相关性能。然后采用模拟和仿真方法对血液在CVCW管管壁径向的流动行为进行评价,量化分析织物组织和锥度角这两个基本纺织结构参数对局部血液流动行为的影响。结果表明,本试验制备的CVCW管壁结构均匀,其织物组织、孔隙率和渗透性会影响流体局部的流动行为,因此,在进行人工血管的设计前必须对织物的结构给予足够的重视。

To analyze the influence of the wall structure on fluid flow behavior of continuous variable cross-sections woven tubular vascular grafts(CVCW), nine CVCW specimens with different wall structures and taper angles were prepared based on the advantages of biomimetic design. Their structural parameters and related properties such as thickness, porosity and water permeability were measured. Then the blood flow behavior in the axial direction of the CVCW vascular grafts was evaluated through simulation method. The effects of weave patterns and taper angles on the local blood flow behavior were quantitatively analyzed. The results show that the local blood flow behavior is affected by the factors of weave patterns, porosity, and water permeability of CVCW vascular grafts, so more attention should be paid in the future design of artificial blood vessels.