巨细胞病毒孕妇血游离β-HCG、凝血4项变化及联合预测不良妊娠结局价值

Predictive value of serum free-β-human chorionic gonadotropin level combined with the levels of blood clotting tetrachoric of pregnant women with cytomegalovirus infection for their adverse pregnancy outcomes

目的:分析游离β-人绒毛促性腺激素(β-HCG)联合凝血4项对巨细胞病毒(HCMV)孕妇妊娠结局的预测价值。方法:选取2018年10月-2021年4月本我院就诊的HCMV感染孕妇58例纳入感染组,产前检查健康孕妇58例纳入对照组,比较感染组与对照组、感染组中不良妊娠结局与良好妊娠结局孕妇的一般临床资料、血βHCG、凝血功能指标差异,分析β-HCG、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)和纤维蛋白原(FIB)预测HMCV感染孕妇发生不良妊娠结局价值。结果:感染组血HCG、APTT、PT、TT水平低于对照组,FIB水平高于对照组,感染组发生不良妊娠结局孕妇血Free-β-HCG、APTT、PT、TT水平均低于良好妊娠结局孕妇,FIB水平高于良好妊娠结局孕妇(均P<0.05)。上述各指标对HCMV感染孕妇不良妊娠结局均有一定预测价值,而联合检测预测的曲线下面积最高(0.903),敏感度85.7%、特异度79.6%。结论:HCMV感染孕妇血游离β-HCG表达降低,血液处于高凝状态,且发生不良妊娠孕妇异常变化更大,各指标联合预测不良妊娠结局的价值较高,对早期干预有一定指导意义。

Objective:To analyze the predictive value of serum free-β-human chorionic gonadotropin(β-HCG)level combined with the levels of blood clotting tetrachoric pregnant women with cytomegalovirus(HCMV)infection for their adverse pregnancy outcomes.Methods:58 pregnant women with HCMV infection were selected in study group,and 58 healthy pregnant women were selected in control group from October 2018 to April 2021.The general clinical data,the levels of bloodβ-HCG and coagulation function indexes were compared between the women in the two groups and between the women with and without adverse pregnancy outcomes in the study group.The values of free-β-HCG,activated partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),and fibrinogen(FIB)of the women with HMCV infection for predicting their adverse pregnancy outcomes was analyzed.Results:The levels of blood HCG,APTT,PT,and TT of the women in the study group were significantly lower than those of the women in the control group,and the FIB level of the women in the study group was significantly higher.In the study group,the levels of blood HCG,APTT,PT,and TT of the women with adverse pregnancy outcomes were significantly lower than those of the women with normal pregnancy outcomes,and the FIB level of the women with adverse pregnancy outcomes was significantly higher(all P<0.05).The levels of blood HCG,APTT,PT,TT,and FIB of the pregnant women with HCMV infection had certain predictive value for their adverse pregnancy outcomes,and the area under the curve of the combined detections of the levels of blood HCG,APTT,PT,TT,and FIB for predicting the adverse pregnancy outcomes was the highest(0.903),with a sensitivity of 85.7%and a specificity of 79.6%.Conclusion:The expression level of freeβ-HCG of the pregnant women with HCMV infection decreases,and the women have the situation of hypercoagulable blood,especially those women with adverse pregnancy outcomes.The combined detections of the levels of blood HCG,APTT,PT,TT,and FIB of the women for predicting their adverse pregnancy outcomes has higher value,which has certain guiding significance for early intervention.