孕中晚期子痫前期患者血清抗米勒管激素、整合素β1水平与子宫螺旋动脉血流参数及血管内皮细胞损伤指标的相关性

Correlation between the levels of serum anti-mullerian hormone and integrinβ-1 of pregnant women with preeclampsia during the second and the third trimester of pregnancy and their uterine spiral artery blood flow parameters and vascular endothelial cell injury indictors

目的:探讨孕中晚期子痫前期患者血清抗米勒管激素(AMH)、整合素β1(ITGβ-1)水平与子宫螺旋动脉血流参数、血管内皮细胞(VEC)损伤指标的相关性。方法:选取2019年3月-2021年3月本院收治的孕中晚期子痫前期患者96例为观察组,产前检查健康孕妇96例为对照组,检测血清AMH、ITGβ-1、子宫螺旋动脉血流参数(PI、RI、S/D)、内皮祖细胞(EPCs)及血管生成性T细胞(Tang),并分析其相关性。结果:观察组AMH(1.62±0.15 ng/ml)、ITGβ-1(0.05±0.02)水平均低于对照组(2.44±0.17 ng/ml、0.18±0.03),子宫螺旋动脉血流参数水平均高于对照组,EPCs(0.08±0.03)%、Tang(47.31±8.57)%水平均低于对照组(0.16±0.05)%、(53.61±7.95)(均P<0.05);AMH、ITGβ-1水平与子宫螺旋动脉血流参数均呈负相关,与VEC损伤指标均呈正相关(均P<0.05)。结论:孕中晚期子痫前期患者血清AMH、ITGβ-1水平异常变化,且与子宫螺旋动脉血流参数及VEC损伤指标均相关。

Objective:To investigate the correlation of the levels of the serum anti-Müllerian hormone(AMH)and integrinβ1(ITGβ-1)of pregnant women with preeclampsia during the second and the third trimester of pregnancy and their uterine spiral artery blood flow parameters and vascular endothelial cell(VEC)injury indictors.Methods:96 pregnant women with preeclampsia during the second and the third trimester of pregnancy were selected in observation group and another 96 healthy pregnant women were selected in control group from March 2019 to March 2021.The serum AMH and ITGβ-1 levels,and the values of uterine spiral artery blood flow parameters,such as PI,RI,and S/D,and the levels of endothelial progenitor cells(EPCs)and angiogenic T cells(Tang)of the women in both groups were measured,and the correlation of which each other was analyzed.Results:The levels of AMH(1.62±0.15 ng/ml)and ITGβ-1(0.05±0.02)of the women in the observation group were significantly lower than those(2.44±0.17 ng/ml and 0.18±0.03)of the women in the control group.The values of the uterine spiral artery blood flow parameters of the women in the observation group were significantly higher than those of the women in the control group.The levels of EPCs(0.08±0.03%)and Tang(47.31±8.57%)of the women in the observation group were significantly lower than those(0.16±0.05%and 53.61±7.95%)of the women in the control group(all P<0.05).The levels of AMH and ITGβ-1 of the women were negatively correlated with their uterine spiral artery blood flow parameters values,and were positively correlated with their VEC injury indexes values(all P<0.05).Conclusion:The levels of serum AMH and ITGβ-1 of the pregnant women with preeclampsia during the second and the third trimester of pregnancy change abnormally,which are correlated with their uterine spiral artery blood flow parameters and their VEC injury.