氨溴索联合布地奈德混悬液雾化吸入对重型新生儿肺炎患儿的影响

Effects of ambroxol combined with budesonide suspension atomization inhalation in children with severe neonatal pneumonia

目的研究氨溴索联合布地奈德混悬液雾化吸入对重型新生儿肺炎患儿肺功能及血清降钙素原(PCT)、白细胞介素-6(IL-6)水平的影响。方法将120例重型新生儿肺炎患儿随机分为对照组和试验组,各60例。对照组给予氨溴索1 mg,加入0.9%氯化钠注射液2 mL中,每日2次,给药时间间隔超过6 h,持续治疗7 d,同时给予氧驱雾化;试验组在对照组基础上加用布地奈德混悬液1 mg,加入0.9%氯化钠注射液2 mL中。比较2组临床疗效,肺功能和血清PCT、IL-6水平变化、临床症状消退时间及药物不良反应发生率。结果治疗后,试验组和对照组的总有效率分别为96.67%和83.33%,差异有统计学意义(P<0.05)。试验组和对照组的咳嗽消失时间分别为(5.35±0.58)和(7.88±1.09)d,发热消失时间分别为(3.42±0.65)和(4.43±0.70)d,肺部啰音消失时间分别为(5.12±0.80)和(5.92±0.84)d,心率恢复时间分别为(2.60±0.59)和(3.75±0.62)d,住院时间分别为(11.10±2.50)和(12.18±3.07)d,差异均有统计学意义(均P<0.05)。治疗后,试验组和对照组的IL-6分别为(77.68±11.64)和(90.35±15.23)pg·mL^(-1),PCT水平分别为(0.53±0.17)和(0.84±0.20)ng·mL^(-1),达峰时间比(TPEF/TE)分别为(38.09±4.34)%和(34.09±3.78)%,达峰容积比(VPEF/VE)分别为(36.56±3.71)%和(33.13±3.73)%,呼吸峰流速(PEF)分别为(72.68±5.65)和(63.98±5.84)mL·s^(-1),差异均有统计学意义(均P<0.05)。结论氨溴索联合布地奈德混悬液氧驱雾化吸入对重型新生儿肺炎患儿疗效更为优越,且安全性良好。

Objective To explore the effect of ambroxol combined with budesonide suspension atomization inhalation on pulmonary function and serum procalcitonin(PCT),interleukin-6(IL-6)levels in children with severe neonatal pneumonia.Methods A total of 120 children with severe neonatal pneumonia were randomly divided into control group and treatment group,with 60 cases in each group.Control group was given ambroxol 1 mg,added into 0.9%NaCl injection 2 mL,twice a day,with an interval of more than 6 h,continuous treatment for 7 days,at the same time,oxygen drive atomization was given;treatment group was given budesonide suspension 1 mg added into 0.9%NaCl injection 2 mL on the basis of control group.The clinical efficacy,pulmonary function,changes in serum PCT and IL-6 levels,clinical symptom subsidence time and incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of treatment group and control group were 96.67% and 83.33%,with statistical significance(P<0.05).The cough disappearance time in treatment group and control group were(5.35±0.58)and(7.88±1.09)d;fever disappearance time were(3.42±0.65)and(4.43±0.70)d;lung rales disappearance time were(5.12±0.80)and(5.92±0.84)d;the recovery time of heart rate were(2.60±0.59)and(3.75±0.62)d;the length of hospital stay were(11.10±2.50)and(12.18±3.07)d;the differences were statistically significant(all P<0.05).After treatment,IL-6 levels in treatment group and control group were(77.68±11.64)and(90.35±15.23)pg·mL^(-1);PCT levels were(0.53±0.17)and(0.84±0.20)ng·mL^(-1);peak arrival time ratio(TPEF/TE)were(38.09±4.34)%and(34.09±3.78)%;peak arrival volume ratio(VPEF/VE)were(36.56±3.71)%and(33.13±3.73)%;peak respiratory velocity(PEF)were(72.68±5.65)and(63.98±5.84)mL·s^(-1);the differences were statistically significant(all P<0.05).Conclusion Ambroxol combined with budesonide suspension liquid oxygen drive nebulized inhalation has better efficacy and good safety for severe neonatal pneumonia.