关于腺病毒是否为近期儿童不明原因肝炎病原的思考

Thoughts on whether adenovirus is the cause of the hepatitis of unknown etiology among children recently

近期,儿童不明原因肝炎在多个国家和地区呈现集中发生的趋势,引起世界卫生组织(WHO)的关注。依据现有病例的相关报道,已有众多假说被提出。其中,关于腺病毒可能是此轮儿童不明原因肝炎病因的推测广受争议。文章从儿童不明原因肝炎的发生、腺病毒的致病特点和腺病毒肝炎的既往报道出发,就可能引起儿童不明原因肝炎的病原进行分析,并就明确病原需开展的工作提出建议,为中国一旦发生相关病例时能够及时、准确地进行诊断提供参考。

Recently,the hepatitis of unknown etiology among children has shown a concentrated trend in many countries and regions,which has aroused concern from the World Health Organization. Based on the reports of existing cases,numerous hypotheses have been proposed,among which the hypothesis that adenovirus may be the cause of the hepatitis of unknown etiology among children is debated widely. According to the occurrence of the hepatitis of unknown etiology among children,the pathogenic characteristics of adenovirus and literatures on adenovirus hepatitis,this review analyzes the pathogens that may cause the hepatitis of unknown etiology among children and puts forward suggestions on the work to be carried out to clarify the pathogens. All of those details may provide a direction for timely and accurate diagnosis of related cases in China.