不同症状首发精神分裂症患者睡眠质量与认知功能的相关性

Correlation between sleep quality and cognitive function in patients with firstonset schizophrenia with different symptoms

目的:探讨首发精神分裂症以阳性和阴性症状为主的患者睡眠质量、认知功能特点以及二者相关性。方法:选取88例住院的首发精神分裂症患者,使用MATRICS共识认知成套测验(MATRICS Consensus Cognition Battery,MCCB)对阳性症状为主组(n=51例)和阴性症状为主组(n=37例)进行认知功能的评估,比较两组患者认知功能的差异和特点,使用匹兹堡睡眠质量指数量表(Pittsburgh Sleep Quality Index,PSQI)对阳性症状为主组(n=51例)和阴性症状为主组(n=37例)进行睡眠质量评估,分别比较两组患者认知功能的差异和睡眠质量的差异,并将两组患者差异部分进行组间比较,采用Pearson相关分析。结果:阳性症状为主的患者的信息处理速度、词语学习、视觉学习、推理和问题解决得分均高于阴性症状为主组,两组差异有统计学意义(t=2.230,3.723,2.055,2.194;P<0.05)。在PSQI各因子中,阳性组患者在催眠药物因子中得分低于阴性组得分,差异有统计学意义(t=-3.066,P<0.05)。进行Pearson相关分析后提示阴性症状为主组患者催眠药物使用与认知功能中视觉学习存在负相关(r=-0.352,P<0.05)。结论:不同症状首发精神分裂症患者在MCCB评估上存在相似的损害,以阴性症状为主组的患者损害程度更重。在睡眠质量方面,二者在催眠药物使用上存在差异,阴性组的患者在催眠药物使用上高于阳性组,与认知功能呈现负相关。

Objective:To explore the characteristics of sleep quality and cognitive function in first-episode schizophrenic patients with positive and negative symptoms,and their correlation.Methods:The MATRICS Consensus Cognition Battery(MCCB)was used to evaluate the cognitive function of 88hospitalized patients with first onset schizophrenia in the main group with positive symptoms(n=51)and the main group with negative symptoms(n=37).The differences and characteristics of cognitive function between two groups were compared.Pittsburgh Sleep Quality Index(PSQI)was used to evaluate the sleep quality of the positive group(n=51cases)and the negative group(n=37cases).The differences in cognitive function and sleep quality between two groups were compared,and the differences between two groups were compared using Pearson correlation analysis.Results:The cognitive function of patients in the positive group in MCCB for information processing speed,word learning,visual learning,reasoning and problem solving were higher than the negative group,the difference was statistically significant(t=2.230,3.723,2.055,2.194;P<0.05).Among the PSQI factors,the score of the positive group of patients in the hypnotic drug factor was lower than the score of the negative group,the difference was statistically significant(t=-3.066,P<0.05).Pearson correlation analysis showed that the use of hypnotics in the negative symptoms-based group was negatively correlated with visual learning in cognitive function(r=-0.352,P<0.05).Conclusion:Patients with first-onset schizophrenia with different symptoms have similar damage in MCCB assessment,and the damage is more severe in the group with negative symptoms.In terms of sleep quality,there is a difference in the use of hypnotic drugs between the two.The use of hypnotic drugs in the negative group is higher than that in the positive group,which is negatively correlated with cognitive function.