葛根素注射液治疗急性心肌梗死后心律失常的临床疗效及对相关指标的影响

Effect of Puerarin Injection on Arrhythmia after Acute Myocardial Infarction

目的观察葛根素注射液治疗急性心肌梗死后心律失常的临床疗效及对心功能、心律、血液流变学等相关指标的影响。方法将98例急性心肌梗死后心律失常患者随机分为观察组和对照组各49例。对照组予以盐酸胺碘酮治疗,0.2 g/次,初始剂量3次/d,第2周2次/d,第3周起维持剂量,共连用4周。观察组在对照组基础上加用葛根素注射液,200mg融入500 mL的葡萄糖注射液,1次/d,静滴,治疗4周。观察两组临床疗效,治疗前后前心功能、心率(HR)、QT离散度(QTd)、血液流变学指标,记录不良反应。结果治疗后观察组临床总有效率高于对照组(P<0.05);两组心功能均改善,观察组优于对照组(P<0.05);两组HR、QTd均改善,观察组优于对照组(P<0.05);治疗后,两组血液流变学均改善,观察组优于对照组(P<0.05)。治疗过程中,不良反应发生率观察组与对照组比较,差异无统计学意义(P>0.05)。结论葛根素注射液治疗急性心肌梗死后心律失常可提高临床疗效,改善心功能、心律、QT离散度及血液流变学指标,且不增加不良反应发生率,值得推广。

Objective To observe the clinical effect of puerarin injection in the treatment of arrhythmia after acute myocardial infarction and its influence on cardiac function,rhythm,hemorheology and other related indexes.Methods 98 patients with arrhythmia after acute myocardial infarction were randomLy divided into observation group and control group with 49.The control group was treated with amiodarone hydrochloride,0.2 g/time,initial dose 3 times/d,2 times/d in the second week,maintenance dose from the third week,a total of 4 weeks.The observation group was additionally treated with puerarin injection,200 mg into 500 mL glucose injection,once a day,intravenous drip,for 4 weeks.The clinical efficacy,heart function,heart rate(HR),QT dispersion(QTd)and hemorheology indexes before and after treatment were observed,and the incidence of adverse reactions in the two groups were recorded.Results After treatment,the total effective rate of the observation group was higher(P<0.05),the cardiac function of the two groups were improved,and the observation group was better(P<0.05),HR and QTd of the two groups were improved,and the observation group were better(P<0.05),the hemorheology of the two groups were improved,and the observation group was better(P<0.05).During the treatment,there was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion Puerarin Injection in the treatment of arrhythmia after acute myocardial infarction can improve the clinical efficacy,cardiac function,rhythm,QT dispersion and hemorheology indexes,and does not increase the incidence of adverse reactions,which is worthy of promotion.