柴胡陷胸汤合蒿芩清胆汤加减治疗癌症放疗后胆汁反流性胃炎

Chaihu Xianxiong Decoction and Haoqin Qingdan Decoction (柴胡陷胸汤合蒿芩清胆汤) in the treatment of bile reflux gastritis in cancer patients after radiotherapy

目的观察柴胡陷胸汤合蒿芩清胆汤加减治疗癌症患者放疗后胆汁反流性胃炎的临床疗效。方法将60例癌症放疗后发生胆汁反流性胃炎的患者随机分为2组,观察组30例服用自拟中药方柴胡陷胸汤合蒿芩清胆汤,对照组30例在接受铝碳酸镁联合奥美拉唑治疗的同时服用莫沙必利。两组均以30 d为1个疗程,疗程结束后电子胃镜复查,对两组患者胃镜下表现及临床疗效进行对照观察。并对两组患者的治疗总有效率、反流总时间比率、反流次数、最长反流时间、反流超过5 min次数、不良反应发生率加以系统比较。结果观察组治疗后各临床症状在胃镜下所见均明显降低,观察组的治疗总有效率93.33%高于对照组的80.00%(P<0.05);两组患者治疗前、治疗后最长反流时间的比较,差异无统计学意义(P>0.05);两组患者治疗前反流总时间比率、反流次数以及反流超过5 min次数的比较,差异无统计学意义(P>0.05);治疗后两组患者反流总时间比率、反流次数以及反流超过5 min次数均比治疗前少,且观察组患者均显著少于对照组(P<0.05);两组不良反应发生率比较无统计学意义(P>0.05)。结论柴胡陷胸汤合蒿芩清胆汤加减治疗癌症患者放疗后胆汁反流性胃炎疗效较好,可使24 h胆汁变化明显减小。

Objective To observe the clinical efficacy of Chaihu Xianxiong Decoction(柴胡陷胸汤合蒿芩清胆汤)and Haoqin Qingdan Decoction in the treatment of bile reflux gastritis in cancer patients after radiotherapy.Methods 60 patients with bile reflux gastritis after cancer radiotherapy were randomLy divided into two groups.30 patients in the treatment group were treated with Chaihu Xianxiong Decoction and Haoqin Qingdan decoction,and 30 patients in the control group were treated with magnesium aluminate combined with omeprazole and Mosapride.Both groups took 30 days as a course of treatment.After the course of treatment,the electronic gastroscope was rechecked.The gastroscopic manifestations and clinical effects of the two groups were compared and observed.The total effective rate,the total time ratio of reflux,the number of reflux,the longest reflux time,the number of reflux exceeding 5 minutes and the incidence of adverse reactions were systematically compared between the two groups.Results after treatment,the clinical symptoms of the treatment group were significantly reduced under gastroscopy.The total effective rate of the treatment group was 93.33%,which was higher than 80.00%of the control group(P<0.05);there was no significant difference in the longest reflux time between the two groups before and after treatment(P>0.05);there was no significant difference in the total time ratio of reflux,the number of reflux and the number of reflux more than 5 minutes between the two groups before treatment(P>0.05);After treatment,the total time ratio of reflux,the number of reflux and the number of reflux exceeding 5 minutes in the two groups were less than those before treatment,and the patients in the treatment group were significantly less than those in the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Chaihu Xianxiong Decoction and Haoqin Qingdan decoction are effective in the treatment of bile reflux gastritis in cancer patients after radiotherapy,and can significantly reduce the change of bile in 24 hours.