摘要
目的:观察理气活血化瘀汤辅助宫腔镜下子宫内膜息肉切除术治疗子宫内膜息肉的临床疗效。方法:选择300例拟行宫腔镜下子宫内膜息肉切除术患者为研究对象,按随机数字表法分为研究组和对照组各150例。对照组给予宫腔镜下子宫内膜息肉切除术治疗,术后给予常规西药治疗,研究组在对照组基础上给予理气活血化瘀汤治疗,2组均连续治疗3个月。比较2组治疗前后孕酮(P)、雌激素(E_(2))、促黄体生成素(LH)、卵泡刺激素(FSH)、孕激素受体(PR)、雌激素受体(ER)、血红蛋白(Hb)、血管内皮生长因子(VEGF)水平,记录2组月经量,检测2组子宫内膜厚度情况,并统计患者术后子宫内膜息肉复发情况。结果:治疗前,2组E_(2)、LH、FSH、P水平比较,差异无统计学意义(P>0.05)。治疗后,2组E_(2)、LH、FSH、P水平较治疗前降低(P<0.05),且研究组E_(2)、LH、FSH、P水平低于对照组(P<0.05)。治疗前,2组ER、PR、Hb、VEGF水平比较,差异无统计学意义(P>0.05)。治疗后,2组ER、PR、VEGF水平较治疗前降低,研究组ER、PR、VEGF水平低于对照组(P<0.05);2组Hb水平较治疗前升高,研究组Hb水平高于对照组(P<0.05)。治疗前,2组子宫内膜厚度及月经量比较,差异无统计学意义(P>0.05)。治疗后,2组子宫内膜厚度及月经量较治疗前降低(P<0.05),且研究组子宫内膜厚度及月经量低于对照组(P<0.05)。研究组复发率为6.67%,低于对照组18.67%,差异有统计学意义(P<0.05)。结论:理气活血化瘀汤用于宫腔镜下子宫内膜息肉切除术后患者,可调节患者激素水平,促进子宫内膜ER、PR表达平衡,抑制子宫内膜增生,使患者月经量恢复正常,降低复发率。
Objective:To observe the clinical effect of Liqi Huoxue Huayu tang assisting hysteroscopic endometrial polypectomy for endometrial polyps.Methods:A total of 300 cases of patients undergoing hysteroscopic endometrial polypectomy were selected as the study objects and divided into the study group and the control group according to the random number table method,with 150 cases in each group.The control group was treated with hysteroscopic endometrial polypectomy and was given routine western medicine after operation;the study group was additionally treated with Liqi Huoxue Huayu tang based on the treatment of the control group.Both groups were treated for three months.The levels of progesterone(P),estrogen(E_(2)),luteinizing hormone(LH),follicle stimulating hormone(FSH)and progesterone receptor(PR),estrogen receptor(ER),hemoglobin(Hb)and vascular endothelial growth factor(VEGF)before and after treatment in the two groups were compared;the menstrual volumes in the two groups were compared;the endometrial thickness in the two groups was detected;the recurrence of endometrial polyps after operation was calculatd.Results:Before treatment,there was no significant difference being found in the comparison of the levels of E_(2),LH,FSH and P between the two groups(P>0.05).After treatment,the levels of E_(2),LH,FSH and P in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of E_(2),LH,FSH and P in the study group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of ER,PR,Hb and VEGF between the two groups(P>0.05).After treatment,the levels of ER,PR and VEGF in the two groups were decreased when compared with those before treatment,and the levels of ER,PR and VEGF in the study group were lower than those in the control group(P<0.05);Hb levels in the two groups were increased when compared with those before treatment,and the Hb level in the study group was higher than that in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of endometrial thickness and menstrual volume between the two groups(P>0.05).After treatment,the endometrial thickness and menstrual volume in the two groups were decreased when compared with those before treatment(P<0.05),and endometrial thickness and menstrual volume in the study group were lower than those in the control group(P<0.05).The recurrence rate was 6.67%in the study group,lower than that of 18.67%in the control group,the difference being significant(P<0.05).Conclusion:The application of Liqi Huoxue Huayu tang for patients after hysteroscopic endometrial polypectomy can regulate their hormone levels,promote the expression balance of ER and PR in endometrium,inhibit endometrial hyperplasia,promote their menstrual volumes returning to normal,and reduce the recurrence rate.
作者
俞陈珠
朱思梦
YU Chenzhu;ZHU Simeng
出处
《新中医》
CAS
2022年第15期113-117,共5页
New Chinese Medicine