甘肃省140例Delta新冠肺炎的流行病学及临床特征

Epidemiological and clinical characteristics of 140 patients with Delta COVID-19 in Gansu Province

目的 分析甘肃省新型冠状病毒(SARS-CoV-2)Delta变异株感染患者的临床特征、实验室检查和影像学检查的差异,为SARS-CoV-2防治提供参考依据。方法 回顾性分析2021年10月-12月甘肃省兰州市第二人民医院雁滩分院和张掖市二院收治的140例SARS-CoV-2变异株Delta感染患者的病历资料、实验室检查和影像学检查结果。结果 140例感染患者,其中男性65例,女性75例;最大年龄87岁,最小年龄1岁8个月,平均年龄(42.65±20.87)岁;确诊患者20%有发热症状;平均核酸持续阳性时间为19.74 d;不同分型患者血清淀粉样蛋白A(SAA)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)、嗜碱性粒细胞(BAS)和淋巴细胞(LYM)表达水平比较有统计学差异;101例(72.14%)患者影像学检查出现肺部病变,轻型、普通型和重型患者肺部影像学异常占比分别为55.81%、73.13%和100%。结论 甘肃省新冠Delta感染患者以轻型和普通型为主;发热患者较少;咳嗽、咳痰、咽部不适为主要临床表现;重型和危重型患者年龄较大,并多患有基础疾病。

OBJECTIVE To analyze the differences of clinical characteristics, laboratory tests and imaging examinations in patients with Novel Coronavirus(SARS-COV-2)Delta variant infection in Gansu province, so as to provide reference for the prevention and treatment of SARS-COV-2. METHODS The medical records, laboratory tests and imaging studies of 140 patients with SARS-COV-2 Delta variant infection admitted to Yantan Branch and Zhangye Second Hospital of Lanzhou Second People’s Hospital from Oct. to Dec. 2021 in Gansu province were retrospectively analyzed. RESULTS Among the 140 infected patients, 65 were males and 75 were females. The oldest was 87 years old, and the youngest was 1 year and 8 months, with an average age of(42.65±20.87) years old. Twenty percent of confirmed patients had fever. The mean duration of positive nucleic acid was 19.74 days. There were significant differences in the expression levels of serum amyloid A(SAA), interleukin-6(IL-6), C-reactive protein(CRP), basophil granulocytes(BAS) and lymphocyte(LYM) in patients with different types. Pulmonary lesions were found in 101 patients(72.14%) by imaging, and the proportion of abnormal lung imaging in mild, ordinary and severe patients accounted for 55.81%, 73.13% and 100% respectively. CONCLUSION The majority of patients with COVID-19 Delta infection in Gansu province were mild and ordinary type. There were fewer fever patients. The main clinical manifestations were cough, expectoration and pharyngeal discomfort. Severe and critically ill patients are older and have more underlying diseases.