血清Galectin-3、MMP-9表达与急性缺血性脑卒中患者静脉溶栓治疗后神经功能缺损的相关性

Correlation between serum galectin-3,MMP-9 expression and neurological deficit after intravenous thrombolysis in patients with acute ischemic stroke

目的探讨血清半乳糖凝集素-3(Galectin-3)、基质金属蛋白酶-9(MMP-9)表达与急性缺血性脑卒中(AIS)患者静脉溶栓治疗后神经功能缺损的关系。方法选取我院静脉溶栓治疗后100例AIS患者,评估所有患者溶栓治疗后神经功能缺损[美国国立卫生研究院卒中量表(NIHSS)]情况,分为重度组(NIHSS评分≥15分,71例)与轻中度组(NIHSS评分在0~14分,29例),重点分析血清Galectin-3、MMP-9水平与AIS患者静脉溶栓治疗后神经功能缺损的关系。结果重度组患者血清Galectin-3、MMP-9水平高于轻中度组(P<0.05);溶栓前血清Galectin-3、MMP-9的高水平可能是AIS患者溶栓治疗后重度神经功能缺损的风险因子(OR=1.385、1.166,P<0.001、=0.002,95%CI 1.160~1.653、1.060~1.282);以及对AIS患者溶栓治疗后重度神经功能缺损风险有一定的预测性能(AUC=0.781、0.718)。结论AIS患者溶栓前血清Galectin-3、MMP-9水平与溶栓治疗后神经功能缺损有关,二者过表达可能会增加重度神经功能缺损风险。

Objective To investigate the relationship between the expression of serum galectin-3 and matrix metalloproteinase-9(MMP-9)and neurological deficit after intravenous thrombolysis in patients with acute ischemic stroke(AIS).Methods The clinical data of 100 patients with AIS who received intravenous thrombolytic therapy in the hospital were retrospectively analyzed.The neurological deficit(NIHSS)of all patients after thrombolytic therapy was evaluated.They were divided into severe group(NIHSS score≥15,71 patients)and mild to moderate group(NIHSS score 0~14,29 patients),and the relationship between the levels of serum galectin-3 and MMP-9 and the neurological deficit after intravenous thrombolytic therapy of AIS patients was analyzed.Results The serum galectin-3 and MMP-9 levels of severe group high than mild to moderate group(P<0.05).The high expression of serum galectin-3 and MMP-9 before thrombolysis may be the risk factors of severe neurological deficit after thrombolysis in AIS patients(OR=1.385、1.166,P<0.001、=0.002,95%CI 1.160~1.653、1.060~1.282).Besides,they can predict the risk of severe neurological deficit in patients with AIS after thrombolytic therapy(AUC=0.781、0.718).Conclusion The levels of serum galectin-3 and MMP-9 in patients with AIS before thrombolysis are related to the neurological deficit after thrombolysis.Their overexpression may increase the risk of severe neurological deficit.