2015—2020年大理市某医院肺炎支原体感染分布和耐药性分析

Analysis of Distribution and Antibiotic Resistance of Mycoplasma pneumoniae Infection in a Hospital in Dali City from 2015 to 2020

目的:分析大理大学第一附属医院2015—2020年肺炎支原体感染的临床分布特点和耐药性变化情况,为临床用药提供参考。方法:对2015—2020年大理大学第一附属医院临床送检口痰标本进行分离培养、菌株鉴定和药敏试验,对数据进行统计分析。结果:共分离得到肺炎支原体标本185株,年度分布呈逐年下降趋势;科室主要来源于呼吸科和感染科;年龄分布主要集中在41~80岁;药敏结果显示:2015—2020年该院肺炎支原体对美满霉素、乙酰螺旋霉素、环丙沙星以及克林霉素整体耐药率差异有统计学意义(P<0.05)。结论:2015—2020年肺炎支原体对抗生素的耐药趋势稳定,应加强耐药性动态监测,从而指导临床合理使用抗生素。

Objective:To analyze the clinical distribution characteristics and antibiotic resistance changes of Mycoplasma pneumoniae infection in the First Affiliated Hospital of Dali University from 2015 to 2020,and to provide reference for clinical medication.Methods:Expectorated or aspirated sputum samples in the First Affiliated Hospital of Dali University from 2015 to 2020were isolated and cultured,strains in them were detected,and antibiotics susceptibility was applied for all isolated bacteria.And then the data were statistically analyzed.Results:A total of 185 strains of Mycoplasma pneumoniae were isolated,and the annual distribution showed a downward trend year by year.Patients mainly came from the Department of Respiratory Medicine and the Department of Infectious Diseases.The age mainly ranged from 41 to 80.The antibiotics susceptibility results showed that there was a statistically significant difference in the overall resistance rates of Mycoplasma pneumoniae to minocycline,acetylspiramycin,ciprofloxacin and clindamycin in this hospital from 2015 to 2020(P<0.05).Conclusion:The resistance trend of Mycoplasma pneumoniae to antibiotics is stable from 2015 to 2020,and the dynamic monitoring of resistance should be strengthened to guide the rational use of antibiotics in clinical practice.