95例局部晚期宫颈腺鳞癌患者的生存及预后分析

Survival and Prognostic Analysis of 95 Case of Locally Advanced Cervical Glands Squamous Cell Carcinoma

目的回顾性分析局部晚期宫颈腺鳞癌患者的生存情况及影响预后的相关因素。方法收集经病理确诊为宫颈腺鳞癌且FIGO分期为ⅠB2-ⅣA期局部晚期患者的临床资料,分析其临床特点、治疗方式及生存情况。结果患者中位年龄为47岁,中位随访110个月,3年及5年的总生存(OS)率为72.8%及62.8%;3年及5年的无疾病进展生存(PFS)率为68.5%和58.5%。COX多因素分析结果显示:年龄≤50岁(P=0.004)、FIGO分期晚(P=0.014)、未行巩固化疗(P=0.045)及淋巴结转移(P=0.002),是晚期宫颈腺鳞癌患者生存差的独立预后因素。结论晚期宫颈腺鳞癌患者预后差、易复发、转移,巩固化疗或可改善生存。

Objective To retrospectively analyze the survival and prognostic factors of patients with locally advanced cervical adenosquamous cell carcinoma.Methods The clinical data of 95 patients with locally advanced cervical adenosquamous carcinoma diagnosed by pathology and FIGO stage IB2-ⅣA were collected to analyze the clinical characteristics,treatment modalities and survival.Results The median age of patients was 47 years old.The median follow-up period is 110 months.The results showed the 3-years and 5-years overall survival(OS)were 72.8%and 62.8%;the 3-years and 5-years disease-free progression survival(PFS)were 68.5%and 58.5%respectively.The results of the COX multivariate analysis showed:Less than 50 years old(P=0.004),advanced FIGO stage(P=0.014),no consolidation chemotherapy(P=0.045)and lymph node metastasis(P=0.002)were independent prognostic factors for poor survival in patients with advanced cervical adenosquamous carcinoma.Conclusion Patients with advanced cervical adenosquamous carcinoma have poor prognosis,easily to relapsed and metastasis.The patients accepting consolidation chemotherapy maybe improve survival.