12~49岁女性人群血硒与机体铁储备关系的横断面研究

A cross-sectional study on the association between blood selenium and total body iron stores in women aged 12-49 years old

目的通过分析美国国家健康与营养监测调查数据库(NHANES)12~49岁女性人群血硒与机体铁储备(TBI)的关系,为预防铁缺乏(ID)提供参考。方法选取NHANES 2017—2018年1665名女性[平均年龄(29.03±11.35)岁]纳入横断面研究,采用多元线性回归分析血硒与TBI的关系。结果调查人群ID发生率为6.97%(116/1665),TBI为(6.99±4.39)mg/kg,血硒为(2.37±0.31)μmol/L。铁盈余组血硒高于ID组(P<0.05)。血硒与TBI呈正相关[β=1.490,95%CI(0.900,2.089),P<0.05]。结论12~49岁女性人群血硒与TBI呈正相关趋势,白蛋白、白细胞(WBC)、超敏C反应蛋白(hs-CRP)、年龄、血汞为协同因素,血锰和红细胞叶酸为拮抗因素。

Objective To analyze the association between blood selenium and total body iron stores(TBI)in women aged 12 to 49 years old in the National Health and Nutrition Examination Survey(NHANES)database,to provide a reference for the prevention of iron deficiency(ID).Methods A total of 1665 women aged 12-49 years old,mean age(29.03±11.35)years,from the NHANES from 2017 to 2018 were included in this cross-sectional analysis.The association between blood selenium and TBI was analyzed using multi-variable linear regression models.Results The incidence of ID was 6.97%(116/1665).The TBI was(6.99±4.39)mg/kg,the blood selenium was(2.37±0.31)μmol/L.The blood selenium in the iron stores group was higher than that in the ID group(P<0.05).Blood selenium was positively associated with TBI[β=1.490,95%CI(0.900,2.089),P<0.05].Conclusion This study suggests that elevated blood selenium levels are correlated with increased TBI in women aged 12-49 years old,and there are synergistic effects with albumin,white blood cell(WBC),hypersensitive C-reactive protein(hs-CRP),age and blood mercury,while blood manganese and red blood cell folate are antagonistic factors.